Results 71 to 80 of about 309,846 (286)

Role of kappa‐opioid and mu‐opioid receptors in pruritus: Peripheral and central itch circuits

Experimental Dermatology, Volume 31, Issue 12, Page 1900-1907, December 2022., 2022
Abstract Modern genetic approaches in animal models have unveiled novel itch‐specific neural pathways, emboldening a paradigm in which drugs can be developed to selectively and potently target itch in a variety of chronic pruritic conditions. In recent years, kappa‐opioid receptors (KORs) and mu‐opioid receptors (MORs) have been implicated in both the ...
Brian S. Kim, Saadet Inan, Sonja Ständer, Thomas Sciascia, Jacek C. Szepietowski, Gil Yosipovitch   +5 more
wiley   +1 more source

Evoke: Evoking Critical Thinking Abilities in LLMs via Reviewer-Author Prompt Editing [PDF]

arXiv, 2023
Large language models (LLMs) have made impressive progress in natural language processing. These models rely on proper human instructions (or prompts) to generate suitable responses. However, the potential of LLMs are not fully harnessed by commonly-used prompting methods: many human-in-the-loop algorithms employ ad-hoc procedures for prompt selection;
arxiv  

Altered stimulus frequency and intensity dependence of the somatosensory evoked potential in rats after acute application of two mitochondrial toxins [PDF]

, 2009
Mitochondrial toxins are a special group of toxicants with nervous system ef TRACT - fects. The resulting nervous system damage could be detected and followed-up by means of functional biomarkers but these still have to be worked out.
Bankó, S., Papp, András, Takács, Sz.
core   +1 more source

Controlling attention to nociceptive stimuli with working memory [PDF]

, 2011
Background: Because pain often signals the occurrence of potential tissue damage, a nociceptive stimulus has the capacity to involuntarily capture attention and take priority over other sensory inputs.
Crombez, Geert, Legrain, Valéry, Mouraux, Andre   +2 more
core   +3 more sources

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Somatic modulation of tinnitus: a review and some open questions [PDF]

, 2016
Tinnitus modulation by movements of the temporomandibular joint, head and neck musculoskeletal structures and the eye, can be found in one to two thirds of tinnitus sufferers; unfortunately this condition is often overlooked by otolaryngologists ...
ALTISSIMI, Giancarlo, CIANFRONE, Giancarlo, RALLI, MASSIMO, TURCHETTA, Rosaria   +3 more
core   +1 more source

Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD. [PDF]

, 2020
Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not completely understood.
Chen, Naiyan, Chen, Qian, Deister, Christopher A, Dimidschstein, Jordane, Feng, Guoping, Feng, Shijing, Fishell, Gord, Gao, Xian, Goard, Michael J, Guo, Baolin, Liao, Weiping, Liu, Runpeng, Lu, Zhonghua, Lynn-Jones, Taylor, Moore, Christopher I, Shi, Yiwu, Wells, Michael F   +16 more
core   +1 more source

The diagnostic accuracy of the small fiber neuropathy symptoms inventory questionnaire (SFN‐SIQ) for identifying pure small fiber neuropathy

Journal of the Peripheral Nervous System, Volume 27, Issue 4, Page 283-290, December 2022., 2022
Abstract A definite diagnosis of pure small fiber neuropathy (SFN) relies on specific diagnostic testing, such as skin biopsy, quantitative sensory testing (QST), and nociceptive evoked potentials, which require considerable resources that may not be widely available.
Eleonora Galosi, Pietro Falco, Giuseppe Di Pietro, Caterina Leone, Nicoletta Esposito, Gianfranco De Stefano, Giulia Di Stefano, Andrea Truini   +7 more
wiley   +1 more source

Monosynaptic connections between pairs of spiny stellate cells in layer 4 and pyramidal cells in layer 5A indicate that lemniscal and paralemniscal afferent pathways converge in the infragranular somatosensory cortex. [PDF]

, 2005
Monosynaptic interlaminar connections between spiny stellate cells in layer 4 (L4), the main cortical recipient layer for thalamic projections, and pyramidal cells in layer 5A (L5A), one of the main cortical output layers, were examined anatomically and ...
Feldmeyer, D, Roth, A, Sakmann, B
core   +1 more source

Haptic BCI Paradigm based on Somatosensory Evoked Potential [PDF]

arXiv, 2012
A new concept and an online prototype of haptic BCI paradigm are presented. Our main goal is to develop a new, alternative and low cost paradigm, with open-source hardware and software components. We also report results obtained with the novel dry EEG electrodes based signal acquisition system by g.tec, which further improves experimental comfort.
arxiv