Results 21 to 30 of about 3,324 (198)

Faire de la recherche son métier ?

Revue d’Histoire des Sciences Humaines, 2019
The French National Fund for the Sciences (the ancestor of the CNRS, the National Fund for Scientific Research) was created in 1930, on the fringes of the university system, to award scholarships and allowances to research scholars, both young and ...
Martine Sonnet
doaj   +1 more source

SON-1010: an albumin-binding IL-12 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy

Frontiers in Immunology
BackgroundCytokines have been promising cancer immunotherapeutics for decades, yet only two are licensed to date. Interleukin-12 (IL-12) is a potent regulator of cell-mediated immunity that activates NK cells and interferon-γ (IFNγ) production.
John K. Cini, Richard T. Kenney, Susan Dexter, Stephen J. McAndrew, Rukiye-Nazan Eraslan, Rich Brody, Darrel J. Rezac, Rebecca Boohaker, Suzanne E. Lapi, Pankaj Mohan   +9 more
doaj   +1 more source

L’émoi des demoiselles en voyage. Du voyage dans quelques journaux intimes de jeunes filles du XIXe siècle

Genre & Histoire, 2012
Travelling Demoiselles’ Emotions : travel in girls’ diaries in the nineteenth centuryThe collection of nineteenth century’s girls’ private diaries studied by Philippe Lejeune (Le moi des demoiselles : enquête sur le journal de jeune fille, 1993) reveals ...
Martine Sonnet
doaj   +1 more source

Direct Least-Squares Rational-Polynomial Lumped-Circuit Model Extraction and Group Theory

IEEE Journal of Microwaves
Given a measured frequency domain response, it is useful to determine the best fit rational polynomial transfer function and then synthesize a corresponding lumped network.
James C. Rautio
doaj   +1 more source

A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers

Frontiers in Immunology
BackgroundThe benefits of recombinant interleukin-12 (rIL-12) as a multifunctional cytokine and potential immunotherapy for cancer have been sought for decades based on its efficacy in multiple mouse models. Unexpected toxicity in the first phase 2 study
Richard T. Kenney, John K. Cini, Susan Dexter, Manuel DaFonseca, Justus Bingham, Isabelle Kuan, Sant P. Chawla, Thomas M. Polasek, Thomas M. Polasek, Jason Lickliter, Philip J. Ryan   +10 more
doaj   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Is Precision Agriculture Technology Adoption Persistently Overestimated?

Agribusiness, EarlyView.
ABSTRACT Precision agriculture is sometimes assumed to diffuse steadily over time, and industry planning frequently extrapolates early adoption trends forward. This study evaluates the accuracy of such expectations by comparing agricultural input dealers' forecasts of future service offerings with the actual levels of offerings that dealerships ...
Trey Malone, Chad Fiechter, Zanliang Meng, James Lowenberg‐DeBoer, Bruce Erickson, Jay Akridge   +5 more
wiley   +1 more source

"The Remains of the Day" : Kazuo Ishiguro's Sonnet on his Blindness = "Lo que queda del día": El Soneto sobre su ceguera, de Kazuo Ishiguro

Cuadernos de Investigación Filológica, 2013
Looking back on a life lived and coming to terms with one’s destiny is the pervading theme of both Milton’s Sonnet XIX and Kazuo Ishiguro’s “The Remains of the Day”.
Rocío G. Davis
doaj   +1 more source

CrossMatAgent: AI‐Assisted Design of Manufacturable Metamaterial Patterns via Multi‐Agent Generative Framework

Advanced Intelligent Discovery, EarlyView.
CrossMatAgent is a multi‐agent framework that combines large language models and diffusion‐based generative AI to automate metamaterial design. By coordinating task‐specific agents—such as describer, architect, and builder—it transforms user‐provided image prompts into high‐fidelity, printable lattice patterns.
Jie Tian, Martin Taylor Sobczak, Dhanush Patil, Jixin Hou, Lin Pang, Arunachalam Ramanathan, Libin Yang, Xianyan Chen, Yuval Golan, Xiaoming Zhai, Hongyue Sun, Kenan Song, Xianqiao Wang   +12 more
wiley   +1 more source

Димитър Тополин и респиритуализирането на сонетната форма

Zeszyty Cyrylo-Metodiańskie, 2018
Dimitar Topolin and the Remodeling of the Sonnet Form. The sonnet in its Shakespearean form holds a prominent place in the poetry of the Bulgarian Orthodox priest Dimitar Popnikolov-Topolin (1886–1962) whose ample oeuvre has only partially been ...
Mihaylov, Kalin
doaj   +1 more source