Results 31 to 40 of about 5,684 (257)

A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers

Frontiers in Immunology
BackgroundThe benefits of recombinant interleukin-12 (rIL-12) as a multifunctional cytokine and potential immunotherapy for cancer have been sought for decades based on its efficacy in multiple mouse models. Unexpected toxicity in the first phase 2 study
Richard T. Kenney, John K. Cini, Susan Dexter, Manuel DaFonseca, Justus Bingham, Isabelle Kuan, Sant P. Chawla, Thomas M. Polasek, Thomas M. Polasek, Jason Lickliter, Philip J. Ryan   +10 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Juanilla y Burguillos: comicidad, ingenio e irreverencia poética

E-Spania, 2021
This article explores the parodic and burlesque reinvention of the Petrarquist sonnet, around the figure of Juana, Juanilla, in the Rimas de Tomé de Burguillos (1634), a muse and washerwoman on Madrid’s river Manzanares.
Milagros Torres
doaj   +1 more source

Angled Nozzle Aerosol Jet Printing to Streamline Conformal Patterning of Electronics

Advanced Materials Technologies, EarlyView.
A modular, angled aerosol jet printhead is demonstrated to streamline patterning on nonplanar surfaces, including 90° step edges and confined internal geometries. A detailed analysis of gravitational settling for a sheathed aerosol flow and deconvolution of oblique deposition and gravitational effects supports the versatility of this approach for ...
Louis O. Morgan, Jeremy D. Rurup, Hal K. Griswold, Md Ramjan Ali, Ethan B. Secor   +4 more
wiley   +1 more source

Receptogenesis in a Vascularized Robotic Embodiment

Advanced Science, EarlyView.
Functional augmentation of situated robots via ex novo hardware generation extends physical adaptability. Drawing inspiration from open circulatory systems for mass and function redistribution, this study presents a vascularized robotic composite exhibiting receptogenesis ‐ the on‐demand construction of sensors ‐ from internal fluid reserves based on ...
Kadri‐Ann Pankratov, Leonid Zinatullin, Hans Priks, Adele Metsniit, Urmas Johanson, Tarmo Tamm, Alvo Aabloo, Edoardo Sinibaldi, Indrek Must   +8 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

"The Remains of the Day" : Kazuo Ishiguro's Sonnet on his Blindness = "Lo que queda del día": El Soneto sobre su ceguera, de Kazuo Ishiguro

Cuadernos de Investigación Filológica, 2013
Looking back on a life lived and coming to terms with one’s destiny is the pervading theme of both Milton’s Sonnet XIX and Kazuo Ishiguro’s “The Remains of the Day”.
Rocío G. Davis
doaj   +1 more source

Metaphors and Novel Allusions, Two Prominent Stylistic Features in Bidel’s Sonnets [PDF]

مطالعات زبانی و بلاغی, 2018
Consciuos avoidance of stereotypically prevalent structures both in meaning and imagination is one of the salient features of Bidel Dehlavis poetry which extensively enhances his works’ innovation, effectiveness and delightfulness.
Rajab Tohidian, Mohammad Akbari Habashi
doaj   +1 more source

Robust NbN‐on‐Si/SiGe Hybrid Microwave Quantum Circuits With Long‐Term Stability

Advanced Electronic Materials, EarlyView.
Superconducting NbN resonators integrated with Si/SiGe quantum wells based semiconducting chip are investigated as a CMOS–compatible platform for scalable quantum hardware. Temperature–dependent microwave spectroscopy reveals loss mechanisms from TLS, quasiparticles, and scattering.
Paniz Foshat, Samane Kalhor, Shima Poorgholam‐khanjari, Douglas Paul, Martin Weides, Kaveh Delfanazari   +5 more
wiley   +1 more source