Results 21 to 30 of about 4,123 (255)

SON-1010: an albumin-binding IL-12 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy

Frontiers in Immunology
BackgroundCytokines have been promising cancer immunotherapeutics for decades, yet only two are licensed to date. Interleukin-12 (IL-12) is a potent regulator of cell-mediated immunity that activates NK cells and interferon-γ (IFNγ) production.
John K. Cini, Richard T. Kenney, Susan Dexter, Stephen J. McAndrew, Rukiye-Nazan Eraslan, Rich Brody, Darrel J. Rezac, Rebecca Boohaker, Suzanne E. Lapi, Pankaj Mohan   +9 more
doaj   +1 more source

Direct Least-Squares Rational-Polynomial Lumped-Circuit Model Extraction and Group Theory

IEEE Journal of Microwaves
Given a measured frequency domain response, it is useful to determine the best fit rational polynomial transfer function and then synthesize a corresponding lumped network.
James C. Rautio
doaj   +1 more source

READING UP THE VERSE PATTERN OF ELIZABETH BARRETT BROWNING S HOW DO I LOVE THEE?

TEFLIN Journal, 2007
Reading a poem is systematic, distinctive and patterned. Written as a sonnet, How do I Love Thee? is akin to neither Shakespearean nor Petrarchan sonnet. The verse pattern of the sonnet is typical: it is composed of two quatrains and one sestet, rhyming
Ariya Jati
doaj   +1 more source

A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers

Frontiers in Immunology
BackgroundThe benefits of recombinant interleukin-12 (rIL-12) as a multifunctional cytokine and potential immunotherapy for cancer have been sought for decades based on its efficacy in multiple mouse models. Unexpected toxicity in the first phase 2 study
Richard T. Kenney, John K. Cini, Susan Dexter, Manuel DaFonseca, Justus Bingham, Isabelle Kuan, Sant P. Chawla, Thomas M. Polasek, Thomas M. Polasek, Jason Lickliter, Philip J. Ryan   +10 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

S‐Nitrosothiols as Thiol‐Protecting Groups for Controlled Thiol‐Maleimide Crosslinking of Homogeneous Soft Hydrogels

Advanced Materials, EarlyView.
Rapid thiol‐maleimide addition frequently outpaces mixing, resulting in heterogeneous hydrogels. S‐nitrosothiols act as thiol‐protecting groups, allowing uniform mixing with maleimide‐functionalized polymers before gelation. Sodium thiosulfate or sodium ascorbate then regenerates thiols on demand, triggering controlled thiol‐maleimide crosslinking ...
Julian A. Serna, Michelle J. Iwohn, Maximilian Seifermann, Stefan Heißler, Maike Schliephake, Franziska Dopp, Claudia Muhle‐Goll, Pavel A. Levkin   +7 more
wiley   +1 more source

Juanilla y Burguillos: comicidad, ingenio e irreverencia poética

E-Spania, 2021
This article explores the parodic and burlesque reinvention of the Petrarquist sonnet, around the figure of Juana, Juanilla, in the Rimas de Tomé de Burguillos (1634), a muse and washerwoman on Madrid’s river Manzanares.
Milagros Torres
doaj   +1 more source

Receptogenesis in a Vascularized Robotic Embodiment

Advanced Science, EarlyView.
Functional augmentation of situated robots via ex novo hardware generation extends physical adaptability. Drawing inspiration from open circulatory systems for mass and function redistribution, this study presents a vascularized robotic composite exhibiting receptogenesis ‐ the on‐demand construction of sensors ‐ from internal fluid reserves based on ...
Kadri‐Ann Pankratov, Leonid Zinatullin, Hans Priks, Adele Metsniit, Urmas Johanson, Tarmo Tamm, Alvo Aabloo, Edoardo Sinibaldi, Indrek Must   +8 more
wiley   +1 more source

"The Remains of the Day" : Kazuo Ishiguro's Sonnet on his Blindness = "Lo que queda del día": El Soneto sobre su ceguera, de Kazuo Ishiguro

Cuadernos de Investigación Filológica, 2013
Looking back on a life lived and coming to terms with one’s destiny is the pervading theme of both Milton’s Sonnet XIX and Kazuo Ishiguro’s “The Remains of the Day”.
Rocío G. Davis
doaj   +1 more source

Is Precision Agriculture Technology Adoption Persistently Overestimated?

Agribusiness, EarlyView.
ABSTRACT Precision agriculture is sometimes assumed to diffuse steadily over time, and industry planning frequently extrapolates early adoption trends forward. This study evaluates the accuracy of such expectations by comparing agricultural input dealers' forecasts of future service offerings with the actual levels of offerings that dealerships ...
Trey Malone, Chad Fiechter, Zanliang Meng, James Lowenberg‐DeBoer, Bruce Erickson, Jay Akridge   +5 more
wiley   +1 more source