Results 1 to 10 of about 3,188 (200)

Exploiting Shock Waves to Trigger the Anticancer Sonodynamic Activity of 5-Aminolevulinc Acid-Derived Protoporphyrin IX on In Vitro 2D and 3D Cancer Models [PDF]

Biomedicines, 2022
Sonodynamic therapy (SDT) is a noninvasive method for cancer treatment based on selective activation of a sonosensitiser by ultrasound (US), which results in the generation of reactive oxygen species (ROS) and cancer cell death.
Federica Foglietta, Patrizia Panzanelli, Loredana Serpe, Roberto Canaparo   +3 more
doaj   +3 more sources

INNV-14. INTERIM REPORT OF A PHASE 1/2 STUDY OF SONODYNAMIC THERAPY (SDT) USING AMINOLEVULINIC ACID (ALA) AND LOW-INTENSITY FOCUSED ULTRASOUND IN PEDIATRIC PATIENTS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) [PDF]

Neuro Oncol, 2023
Abstract BACKGROUND DIPGs are devastating pediatric brain tumors with limited treatment options, poor prognosis, and survival of 9-11 months. Preclinical studies demonstrate that performing SDT through MR-guided focused ultrasound (MRgFUS) activates ALA metabolite, protoporphyrin IX (PpIX), leading to
Hasan Syed, Lindsay Kilburn, Roger Packer, Robert Keating, Sabine Mueller, Nirali Patel, Peter Fenn, Ryan Clanton, Corina Andresen, Stuart Marcus, Ely Benaim   +10 more
europepmc   +2 more sources

Theranostic Uses of the Heme Pathway in Neuro-Oncology: Protoporphyrin IX (PpIX) and Its Journey from Photodynamic Therapy (PDT) through Photodynamic Diagnosis (PDD) to Sonodynamic Therapy (SDT). [PDF]

Cancers (Basel)
ALA PDT, first approved as a topical therapy to treat precancerous skin lesions in 1999, targets the heme pathway selectively in cancers. When provided with excess ALA, the fluorescent photosensitizer PpIX accumulates primarily in cancer tissue, and ALA PDD is used to identify bladder and brain cancers as a visual aid for surgical resection.
Marcus SL, de Souza MP.
europepmc   +3 more sources

TRLS-17. INTERIM CLINICAL, PHARMACOKINETIC, AND TECHNICAL REPORT OF A PHASE 2 STUDY OF SONODYNAMIC THERAPY (SDT) USING SONALA-001 TOGETHER WITH MR-GUIDED LOW-INTENSITY FOCUSED ULTRASOUND (MRGFUS) IN CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) [PDF]

Neuro Oncol
Abstract BACKGROUND Children with DIPG have limited treatment options and poor prognosis with median survival of 9-12 months. Preclinical studies reveal that sonodynamic therapy (SDT) via MR-guided focused ultrasound (MRgFUS) activates SONALA-001 (ALA) metabolite, protoporphyrin IX (PpIX), inducing ...
Syed, Hasan R, Packer, Roger J, Fonseca, Adriana, Keating, Robert F, Mueller, Sabine, Narsinh, Kazim, Ho, Winson, Niazi, Toba, Fenn, Peter, Clanton, Ryan, Henry, Lenora, Potter, Wyatt, Andresen, Corina, Marcus, Stuart, Benaim, Ely, Kilburn, Lindsay   +15 more
europepmc   +2 more sources

CTNI-74. SONODYNAMIC THERAPY (SDT) USING INTRAVENOUS 5-AMINOLEVULINIC ACID WITH NON-ABLATIVE FOCUSED ULTRASOUND FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS IN PEDIATRICS: INITIAL SAFETY AND OUTCOMES THE MULTICENTER SDT-201 TRIAL [PDF]

Neuro Oncol
Abstract Diffuse intrinsic pontine glioma (DIPG) is the leading cause of mortality amongst pediatric neuro-oncologic diseases. Sonodynamic therapy with non-ablative MR-guided focused ultrasound (MRgFUS) is being investigated in multiple clinical trials.
Lindsay Kilburn, Robert Keating, Nirali Patel, Adriana Fonseca, Dan Donoho, Chima Oluigbo, John Myseros, Kazim Narsinh, Sabine Mueller, Winson Ho, Ziad Khatib, Toba Niazi, Ryan Clanton, Lenora Henry, Wyatt Potter, Stuart Marcus, Ely Benaim, Roger Packer, Hasan Syed   +18 more
europepmc   +2 more sources

Nanosonotechnology: the next challenge in cancer sonodynamic therapy [PDF]

Nanotechnology Reviews, 2012
Sonodynamic therapy (SDT) is a newly developed anticancer treatment where ultrasound is used to trigger the cytotoxic effect of chemical compounds, known as sonosensitizers.
Serpe Loredana, Foglietta Federica, Canaparo Roberto   +2 more
doaj   +2 more sources

Copper-coordinated engineered nanoreactors with self-amplifying O2 and cascade chem-drug synthesis for enhanced sonodynamic-mediated oncotherapy [PDF]

Journal of Nanobiotechnology
Efficient synthesis of chemotherapeutic drugs within the tumor microenvironment (TME) holds great potential for enhancing sonodynamic-mediated synergistic oncotherapy.
Zhongxiong Fan, Lijun Ding, Fukai Zhu, Nan Yang, Yanrong Shi, Qian Sun, Jun Hai, Jinyao Li, Guanghao Su, Zhenqing Hou   +9 more
doaj   +2 more sources

Optimizing energy transfer in NIR ruthenium(II) complexes to enhance stability and efficiency in sonodynamic therapy [PDF]

Ultrasonics Sonochemistry
Recent advancements in nanomedicine have driven the development of multifunctional theranostic platforms for targeted cancer therapy. Sonodynamic therapy (SDT) holds a distinct advantage over traditional photodynamic therapy (PDT) by harnessing ...
Dazhuang Xu, Qixuan Dai, Jian Sun, Yibo An, Ziying Wang, Lijuan Yang, Zhixiang Lu, Chengchao Chu, Gang Liu   +8 more
doaj   +2 more sources

O-P03 A composite polymeric nanoparticle as a sensitiser for sonodynamic therapy (SDT)-based treatment of pancreatic cancer [PDF]

British Journal of Surgery, 2021
Abstract Background Pancreatic cancer remains one of the most recalcitrant forms of cancer with poor prognosis and limited treatment options. SDT is a novel, targeted approach to the treatment of solid tumours.
Sian Farrell, Heather Nesbitt, Laura Mairs, Nikolitsa Nomikou, Bridgeen Callan, John F. Callan, Anthony P. McHale   +6 more
openaire   +1 more source

Nanosensitizer-assisted sonodynamic therapy for breast cancer [PDF]

Journal of Nanobiotechnology
Breast cancer is the most commonly diagnosed cancer worldwide. Despite advancements in therapeutic modalities, its prognosis remains poor owing to complex clinical, pathological, and molecular characteristics.
Jing Yu, Jun-Rui Hu, Yi Tian, Yu-Meng Lei, Hai-Man Hu, Bing-Song Lei, Ge Zhang, Yao Sun, Hua-Rong Ye   +8 more
doaj   +2 more sources