Results 171 to 180 of about 3,188 (200)

Phase 1/2, first-in-child study of sonodynamic therapy (SDT) using low intensity focused ultrasound and 5-aminolevulinic acid (ALA) for patients with diffuse intrinsic pontine glioma.

Journal of Clinical Oncology, 2023
TPS10070 Background: Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric brain tumor with poor prognosis. Sonodynamic therapy (SDT) with ALA is a non-invasive strategy that sensitizes target tissues with a non-toxic chemical agent followed by exposure to low intensity MR-guided focused ultrasound (MRgFUS).
Hasan R Syed, Nirali Patel, Lindsay Baker Kilburn, Adriana Fonseca, Kristen Stabingas, Ryan Clanton, Stuart Marcus, Gilbert Vezina, Javad Nazarian, Robert F Keating, Roger J. Packer   +10 more
openaire   +1 more source

SONODYNAMIC THERAPY (SDT) AND GENE THERAPY

CARDIOMETRY, 2023
One in Four Deaths in Japan Caused by Cancer. Cancer is the most common cause of death for Japanese people who are 40 and over, while suicide is the leading cause among young people.
openaire   +1 more source

Sonodynamic therapy (SDT): a novel strategy for cancer nanotheranostics

Science China Life Sciences, 2018
Sonodynamic therapy (SDT) is a promising non-invasive therapeutic modality. Compared to photo-inspired therapy, SDT provides many opportunities and benefits, including deeper tissue penetration, high precision, less side effects, and good patient compliance. Thanks to the facile engineerable nature of nanotechnology, nanoparticles-based sonosensitizers
Xueting, Pan, Hongyu, Wang, Shunhao, Wang, Xiao, Sun, Lingjuan, Wang, Weiwei, Wang, Heyun, Shen, Huiyu, Liu   +7 more
openaire   +2 more sources

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Advanced Materials, 2016
The fast development of photoactivation for cancer treatment provides an efficient photo‐therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal therapy suffers from the critical issue of low in vivo penetration depth of tissues.
Xiaoqin, Qian, Yuanyi, Zheng, Yu, Chen
openaire   +2 more sources

Primary clinical use of sonodynamic therapy (SDT) for advanced breast cancer

Journal of Clinical Oncology, 2008
12029 Background: There are increasing data showing that sonodynamic therapy (SDT), which refers to a synergistic effect of drugs and ultrasound, is a promising new modality for cancer treatment.
X. J. Wang, D. Mitchell, T. J. Lewis
openaire   +1 more source

Sonodynamic therapy (SDT): A novel treatment of cancer based on sonosensitizer liposome as a new drug carrier

Medical Hypotheses, 2013
Cancer is a major cause of morbidity and mortality. Chemotherapy is one of the main means of cancer treatment. Conventional chemotherapy agents kill rapidly proliferating cells, resulting in some of the most common side effects of chemotherapy. Liposome-encapsulated drugs offer the possibility to increase target efficacy as well as reducing toxic side ...
Zhi-Jun, Dai, Sha, Li, Jie, Gao, Xiao-Na, Xu, Wang-Feng, Lu, Shuai, Lin, Xi-Jing, Wang   +6 more
openaire   +2 more sources

Interim report of a phase 2 study of sonodynamic therapy (SDT) using SONALA-001 together with MR-guided low-intensity focused ultrasound (MRgFUS) in children with diffuse intrinsic pontine glioma (DIPG).

Journal of Clinical Oncology
2067 Background: Children with DIPG have limited treatment options and a poor prognosis, with median survival of 9-12 months. Preclinical studies reveal that sonodynamic therapy (SDT) with MR-guided focused ultrasound (MRgFUS) activates ALA metabolite, protoporphyrin IX (PpIX), leading to tumor cell death and extending survival in glioma models ...
Lindsay Baker Kilburn, Roger J. Packer, Adriana Fonseca, Robert F Keating, Sabine Mueller, Kazim Narsinh, Winson S Ho, Toba Niazi, Peter Fenn, Ryan Clanton, Lenora Henry, Wyatt Potter, Corina Andresen, Stuart Marcus, Ely Benaim, Hasan R Syed   +15 more
openaire   +1 more source

1151 Sonodynamic Therapy (SDT) Using Intravenous 5-aminolevulinic Acid With MR-Guided Focused Ultrasound (MRgFUS) for the Treatment of Diffuse Intrinsic Pontine Gliomas in Pediatrics: Initial Safety and Outcomes of the Multicenter SDT-201 Trial

Neurosurgery
INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is the leading cause of mortality amongst pediatric neuro-oncologic diseases. Sonodynamic therapy with MR-guided focused ultrasound (MRgFUS) is being investigated in multiple clinical trials.
Kelsi M. Chesney, Gregory F. Keating, Nirali Patel, Lindsay Kilburn, Adriana Fonseca Sheridan, Daniel Donoho, Chima Oluigbo, John Myseros, Kazim Narsinh, Sabine Mueller, Winson Ho, Toba Niazi, Ziad Khatib, Ryan Clanton, Lenora Henry, Wyatt Potter, Stuart Marcus, Ely Benaim, Roger Packer, Robert F. Keating, Hasan R. Syed   +20 more
openaire   +1 more source

State of the art advancements in sonodynamic therapy (SDT): Metal-Organic frameworks for SDT

Chemical Engineering Journal, 2022
Zuoxiu Xiao, Qiaohui Chen, Yuqi Yang, Shiqi Tu, Boyu Wang, Yige Qiu, Yitian Jiang, Qiong Huang, Kelong Ai   +8 more
openaire   +1 more source

Radiation therapy‐associated toxicity: Etiology, management, and prevention

Ca-A Cancer Journal for Clinicians, 2021
Kyle Wang
exaly