Results 141 to 150 of about 1,400 (162)

Ultrasound-dependent cytoplasmic internalization of a peptide-sonosensitizer conjugate

Bioorganic & Medicinal Chemistry, 2017
A method to induce cytoplasmic peptide delivery, using ultrasound, was demonstrated using a molecular conjugate of a cell-penetrating peptide (CPP), a functional peptide, and a sonosensitizer. As a model of such molecular conjugates, TatBim-RB, consisting of the Tat CPP, the Bim apoptosis inducing peptide, and the sonosensitizer rose bengal was ...
Yuki, Inaba, Kazunori, Watanabe, Mizuki, Kitamatsu, Eiji, Nakata, Atsushi, Harada, Takashi, Ohtsuki   +5 more
openaire   +2 more sources

Immunosonodynamic Therapy Designed with Activatable Sonosensitizer and Immune Stimulant Imiquimod

ACS Nano, 2022
Sonodynamic therapy (SDT) has garnered extensive attention as a noninvasive treatment for deep tumors. Furthermore, imiquimod (R837), an FDA-approved toll-like receptor 7 agonist, is commonly used in clinical settings as an immune adjuvant. We prepared an activatable sonodynamic sensitizer platform (MR) based on glutathione-sensitive disulfide bonds ...
Huali Lei, Ji Hyeon Kim, Subin Son, Linfu Chen, Zifan Pei, Yuqi Yang, Zhuang Liu, Liang Cheng, Jong Seung Kim   +8 more
openaire   +2 more sources

A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide

Nature Biomedical Engineering
The antimicrobial effect of antimicrobial peptides is typically slow; they can be rapidly biodegraded and often have non-selective toxicity and elaborate sequences. Here we report a short peptide that is activated by ultrasound, that shows high broad-spectrum antibacterial efficiency (>99%) against clinically isolated methicillin-resistant bacteria ...
Xiaoguang Zhang, Xiaobo Feng, Liang Ma, Jie Lei, Gaocai Li, Weifeng Zhang, Huaizhen Liang, Bide Tong, Di Wu, Cao Yang, Lei Tan   +10 more
openaire   +2 more sources

Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Small
AbstractSonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising therapy approach for deep‐seated tumors. However, the general or only utilization of SDT shows low efficiency and unsatisfactory treatment outcomes due to the complicated tumor microenvironment (TME) and SDT process.
Fuhong Yang, Jingqi Lv, Wen Ma, Yanling Yang, Xiaoming Hu, Zhen Yang   +5 more
openaire   +2 more sources

Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy

Advanced Functional Materials
AbstractSonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years.
Jiajun Chen, Qi Zhou, Wenwu Cao
openaire   +1 more source

Sonosensitizers for Sonodynamic Therapy: Current Progress and Future Perspectives

Ultrasound in Medicine & Biology
Sonodynamic therapy (SDT) is a novel non-invasive treatment method that combines low-intensity ultrasound and sonosensitizers. Compared with photodynamic therapy, SDT has the advantages of deeper tissue penetration, higher accuracy and fewer adverse reactions. Sonosensitizers are essential for the efficacy of SDT. Sonosensitizers have the advantages of
Ting Wang, Meng Du, Zhiyi Chen
openaire   +2 more sources

Tumor growth inhibition by sonodynamic therapy using a novel sonosensitizer

Free Radical Biology and Medicine, 2012
Sonodynamic therapy (SDT) with low-intensity ultrasound combined with a sonosensitizer may be a promising approach to cancer therapy. Use of ultrasound has the advantage of being noninvasive, with deep-penetration properties, and convenient because of the low or no sensitivity of sonosensitizers to light. In this study, SDT with a novel sonosensitizer (
Hirofumi, Tsuru, Hirotomo, Shibaguchi, Motomu, Kuroki, Yuichi, Yamashita, Masahide, Kuroki   +4 more
openaire   +2 more sources

Exosome‐Inhibiting Polymeric Sonosensitizer for Tumor‐Specific Sonodynamic Immunotherapy

Advanced Materials
AbstractCombination cancer immunotherapy based on electromagnetic energy and immunotherapy shows potent anti‐cancer efficacy. However, as a factor that mediates tumor metastasis and immune suppression, the impact of tumor exosomes on therapy under electromagnetic energy stimulation remains unclear.
Jiayan Wu, Jingsheng Huang, Jie Yu, Mengke Xu, Jing Liu, Kanyi Pu   +5 more
openaire   +3 more sources

Exploring BODIPY derivatives as sonosensitizers for anticancer sonodynamic therapy

European Journal of Medicinal Chemistry
Sonodynamic therapy (SDT) is an emerging non-invasive and effective therapeutic modality for cancer treatment bearing benefit of deep tissue-penetration in comparison to photo-inspired therapy. However, exploring novel sonosensitizers with high sonosensitivity and desirable biosafety remains a significant challenge.
Xudong Li, Xianbin Sun, Hui Chen, Xinyu Chen, Yuanming Li, Dongmiao Li, Zizhong Zhang, Haijun Chen, Yu Gao   +8 more
openaire   +2 more sources

Sonodynamic therapy of cancer using novel sonosensitizers.

Anticancer research, 2007
Sonodynamic therapy (SDT) of cancer is based on preferential uptake and/or retention of a sonosensitizing drug (sonosensitizer) in tumor tissues and subsequent activation of the drug by ultrasound irradiation. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer.
Masahide, Kuroki, Ken, Hachimine, Hironori, Abe, Hirotomo, Shibaguchi, Motomu, Kuroki, Shin-Ichi, Maekawa, Jun, Yanagisawa, Tetsushi, Kinugasa, Toshihiro, Tanaka, Yuichi, Yamashita   +9 more
openaire   +1 more source