Results 171 to 180 of about 1,986 (208)

Ultrasound-excited temozolomide sonosensitization induces necroptosis in glioblastoma

Cancer Letters, 2023
Temozolomide (TMZ) has been determined to be the chemotherapeutic drug with efficacy for glioblastoma (GBM). Thus, potentiating the therapeutic effect of TMZ can undoubtedly yield twice the result with half the effort. In this study, we found for the first time that TMZ can produce reactive oxygen species (ROS) under the influence of ultrasound (US ...
Fanchen, Wang, Lixia, Xu, Binli, Wen, Sirong, Song, Yan, Zhou, Haiyang, Wu, Qiaoli, Wu, Yinsong, Wang, Xiaoguang, Tong, Hua, Yan   +9 more
openaire   +2 more sources

2D Nano‐Sonosensitizers Facilitate Energy Transfer to Enhance Sonodynamic Therapy

Advanced Materials, 2023
AbstractAlthough sonodynamic therapy (SDT) has shown promise for cancer treatment, the lack of efficient sonosensitizers (SSs) has limited the clinical application of SDT. Here, a new strategy is reported for designing efficient nano‐sonosensitizers based on 2D nanoscale metal–organic layers (MOLs).
Geoffrey T Nash, Taokun Luo, Indranil Ghosh   +2 more
exaly   +4 more sources

Erbium oxide nanoplates as a sonosensitizer devoid of photosensitivity

Chemical Communications, 2023
Er2O3 nanoplates could be a sensitizer for sonodynamic therapy without phototoxicity.
Yingfan Dai, Ruihao Yang, Zeinab Marfavi, Quanjie Lv, Yijun Han, Kang Sun, Danhong Wu, Ke Tao   +7 more
openaire   +2 more sources

Natural products in the discovery of novel sonosensitizers

Pharmacology & Therapeutics, 2016
Sonodynamic therapy (SDT), which involves a combination of low-intensity ultrasound and chemotherapeutic agents called sonosensitizers, has been developed for its promising, distinct advantages, such as its noninvasive nature relative to traditional surgery and radiotherapy, greater accessibility to treat deeply located diseases than photodynamic ...
Xin Pang, Yue Jiang, Qicai Xiao
exaly   +3 more sources

Live bio-nano-sonosensitizer targets malignant tumors in synergistic therapy

Acta Biomaterialia, 2023
Sonosensitizers that can increase the concentration of reactive oxygen species (ROS) within a tumor microenvironment is a high priority for sonodynamic therapy (SDT). In this study, a functionalized, smart nanosonosensitizer based on Au-RuO2 nanoparticles (NPs) and selenium nanoparticles (Se NPs) that were electrostatically self-assembled onto the ...
Chenyang Yin, Yuqing Li, Ziyu Liao, Zekun Wang, Chunxue Dai, Weiyun Wang, Endong Yang, Feng Guo, India R. Wright, Lisandra L. Martin, Dongdong Sun   +10 more
openaire   +2 more sources

[Sonosensitizing Action of Teraphtal in Bacterial Media].

Biofizika, 2015
Employing bacterial model systems it was shown that the introduction of the soluble compound--sodium salt of cobalt octacarboxyphthalocyanine (teraphtal)--into the medium led in an ultrasonic field to a decrease in the proportion of survived bacteria.
S E, Mazina, A Y, Gopin, A L, Nikolaev, P I, Talberg   +3 more
openaire   +3 more sources

Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy

Journal of Controlled Release, 2023
Sonodynamic therapy (SDT) has emerged as an effective therapeutic modality as it employs ultrasound (US) to eradicate deep-seated tumors noninvasively. However, the therapeutic efficacy of SDT in clinical settings remains limited owing to the low aqueous stability and poor pharmacokinetic properties of sonosensitizers.
Thuy Giang, Nguyen Cao, Quan, Truong Hoang, Eun Ji, Hong, Su Jin, Kang, Ji Hee, Kang, Vasanthan, Ravichandran, Han Chang, Kang, Young Tag, Ko, Won Jong, Rhee, Min Suk, Shim   +9 more
openaire   +2 more sources

Ultrasound-dependent cytoplasmic internalization of a peptide-sonosensitizer conjugate

Bioorganic & Medicinal Chemistry, 2017
A method to induce cytoplasmic peptide delivery, using ultrasound, was demonstrated using a molecular conjugate of a cell-penetrating peptide (CPP), a functional peptide, and a sonosensitizer. As a model of such molecular conjugates, TatBim-RB, consisting of the Tat CPP, the Bim apoptosis inducing peptide, and the sonosensitizer rose bengal was ...
Yuki, Inaba, Kazunori, Watanabe, Mizuki, Kitamatsu, Eiji, Nakata, Atsushi, Harada, Takashi, Ohtsuki   +5 more
openaire   +2 more sources

Immunosonodynamic Therapy Designed with Activatable Sonosensitizer and Immune Stimulant Imiquimod

ACS Nano, 2022
Sonodynamic therapy (SDT) has garnered extensive attention as a noninvasive treatment for deep tumors. Furthermore, imiquimod (R837), an FDA-approved toll-like receptor 7 agonist, is commonly used in clinical settings as an immune adjuvant. We prepared an activatable sonodynamic sensitizer platform (MR) based on glutathione-sensitive disulfide bonds ...
Huali Lei, Ji Hyeon Kim, Subin Son, Linfu Chen, Zifan Pei, Yuqi Yang, Zhuang Liu, Liang Cheng, Jong Seung Kim   +8 more
openaire   +2 more sources

A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide

Nature Biomedical Engineering
The antimicrobial effect of antimicrobial peptides is typically slow; they can be rapidly biodegraded and often have non-selective toxicity and elaborate sequences. Here we report a short peptide that is activated by ultrasound, that shows high broad-spectrum antibacterial efficiency (>99%) against clinically isolated methicillin-resistant bacteria ...
Xiaoguang Zhang, Xiaobo Feng, Liang Ma, Jie Lei, Gaocai Li, Weifeng Zhang, Huaizhen Liang, Bide Tong, Di Wu, Cao Yang, Lei Tan   +10 more
openaire   +2 more sources