Results 181 to 190 of about 1,986 (208)

Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Small
AbstractSonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising therapy approach for deep‐seated tumors. However, the general or only utilization of SDT shows low efficiency and unsatisfactory treatment outcomes due to the complicated tumor microenvironment (TME) and SDT process.
Fuhong Yang, Jingqi Lv, Wen Ma, Yanling Yang, Xiaoming Hu, Zhen Yang   +5 more
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Sonosensitizers for Sonodynamic Therapy: Current Progress and Future Perspectives

Ultrasound in Medicine and Biology
Sonodynamic therapy (SDT) is a novel non-invasive treatment method that combines low-intensity ultrasound and sonosensitizers. Compared with photodynamic therapy, SDT has the advantages of deeper tissue penetration, higher accuracy and fewer adverse reactions. Sonosensitizers are essential for the efficacy of SDT. Sonosensitizers have the advantages of
Yue Li
exaly   +3 more sources

Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy

Advanced Functional Materials
AbstractSonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years.
Jiajun Chen, Qi Zhou, Wenwu Cao
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Tumor growth inhibition by sonodynamic therapy using a novel sonosensitizer

Free Radical Biology and Medicine, 2012
Sonodynamic therapy (SDT) with low-intensity ultrasound combined with a sonosensitizer may be a promising approach to cancer therapy. Use of ultrasound has the advantage of being noninvasive, with deep-penetration properties, and convenient because of the low or no sensitivity of sonosensitizers to light. In this study, SDT with a novel sonosensitizer (
Hirofumi, Tsuru, Hirotomo, Shibaguchi, Motomu, Kuroki, Yuichi, Yamashita, Masahide, Kuroki   +4 more
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Exosome‐Inhibiting Polymeric Sonosensitizer for Tumor‐Specific Sonodynamic Immunotherapy

Advanced Materials
AbstractCombination cancer immunotherapy based on electromagnetic energy and immunotherapy shows potent anti‐cancer efficacy. However, as a factor that mediates tumor metastasis and immune suppression, the impact of tumor exosomes on therapy under electromagnetic energy stimulation remains unclear.
Jiayan Wu, Jingsheng Huang, Jie Yu, Mengke Xu, Jing Liu, Kanyi Pu   +5 more
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Exploring BODIPY derivatives as sonosensitizers for anticancer sonodynamic therapy

European Journal of Medicinal Chemistry
Sonodynamic therapy (SDT) is an emerging non-invasive and effective therapeutic modality for cancer treatment bearing benefit of deep tissue-penetration in comparison to photo-inspired therapy. However, exploring novel sonosensitizers with high sonosensitivity and desirable biosafety remains a significant challenge.
Xudong Li, Xianbin Sun, Hui Chen, Xinyu Chen, Yuanming Li, Dongmiao Li, Zizhong Zhang, Haijun Chen, Yu Gao   +8 more
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Sonodynamic therapy of cancer using novel sonosensitizers.

Anticancer research, 2007
Sonodynamic therapy (SDT) of cancer is based on preferential uptake and/or retention of a sonosensitizing drug (sonosensitizer) in tumor tissues and subsequent activation of the drug by ultrasound irradiation. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer.
Masahide, Kuroki, Ken, Hachimine, Hironori, Abe, Hirotomo, Shibaguchi, Motomu, Kuroki, Shin-Ichi, Maekawa, Jun, Yanagisawa, Tetsushi, Kinugasa, Toshihiro, Tanaka, Yuichi, Yamashita   +9 more
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Sonodynamic antitumor effect of a novel sonosensitizer on S180 solid tumor

Biopharmaceutics & Drug Disposition, 2013
ABSTRACTPurpose: The purpose of this study was to evaluate the sonodynamically induced antitumor effect of a novel sonosensitizer (DVDMS) in mice bearing sarcoma 180 solid tumors. Methods: In order to determine the optimum timing of ultrasound exposure after administration of DVDMS, a three‐dimensional optical imaging system (IVIS spectrum) was used to
Caifeng, Li, Kun, Zhang, Pan, Wang, Jianmin, Hu, Quanhong, Liu, Xiaobing, Wang   +5 more
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Programmable Bacterial Architects Crafting Sonosensitizers for Tumor‐Specific Sonodynamic Immunotherapy

Advanced Materials
AbstractSonodynamic therapy (SDT) is a non‐invasive cancer treatment that uses ultrasound to activate sonosensitizers for selective tumor ablation. With its superior tissue penetration compared to photodynamic therapy, SDT demonstrates the potential to stimulate antitumor immune responses by modulating the tumor microenvironment.
Zuo Yang, Zhiping Jiao, Zhuang Chen, Chaoqiang Qiao, Chuting Huang, Lingyun Wang, Zhiping Rao, Ruili Zhang, Zhongliang Wang   +8 more
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Formulation and Characterization of Sonosensitive Organic Nanoparticles

2021
In den pharmazeutischen Wissenschaften scheinen nanoskalige Formulierungen die Antwort auf viele neue Therapie- und Diagnoseansätze zu sein [1]. Über 350 Studien zu verschiedenen Nanopartikelformulierungen und Indikationsgebieten werden derzeit in klinischen Studien durchgeführt, von denen allerdings nur 26 die Phase 3 erreicht haben [2]. Sie sind auch
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