Results 41 to 50 of about 16,175 (293)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
History of Thought and History of Humankind in Plato’s Protagoras
PeithoIn Plato’s Protagoras, prompted by Socrates, Protagoras grapples with the complex problem of the nature of the sophistike techne that he professes. To clarify the nature of his teaching, he reconstructs a history of his discipline, identifying a series ...
Michele Corradi
doaj +1 more source
Peter Redpath’s Philosophy of History [PDF]
Studia Gilsoniana, 2016 Peter Redpath is a distinguished historian of philosophy. He believes that the best way to acquire a philosophical education is through the study of philosophy’s history.
Curtis L. Hancock
doaj
The Fundamental Metaphor of Sophistry
Educação & Realidade, 2022 This paper analyzes the metaphor as a discursive strategy to explain and disseminate the concepts that support doctrines in general and educational doctrines in particular.
Tatiane Silva, Marcus Vinicius Cunha
doaj
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Hoe post-modern is postmodernisme? Enkele gedagtes
Acta Theologica, 1998 It is imperative for the Christian to confront Post-Modernism and try to gauge its meaning(s). The very term Post-Modernism seems to breathe the fresh eschatological air of being 'with it' in a super way - past the modern age and in uncharted waters ...
L F Schulze
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Demagog i sofista nauczycielami wiedzy w demokracji masowej [PDF]
, 2016 The Author characterises mass democracy as a world where people encounter great science, great pathologies in science and great confusion in languages. He discusses the status and function of demagogy and demagogues as well as sophistry and sophists in ...
Goćkowski, Janusz
core +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source