Results 41 to 50 of about 16,193 (291)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Peter Redpath’s Philosophy of History [PDF]
Studia Gilsoniana, 2016 Peter Redpath is a distinguished historian of philosophy. He believes that the best way to acquire a philosophical education is through the study of philosophy’s history.
Curtis L. Hancock
doaj
The Fundamental Metaphor of Sophistry
Educação & Realidade, 2022 This paper analyzes the metaphor as a discursive strategy to explain and disseminate the concepts that support doctrines in general and educational doctrines in particular.
Tatiane Silva, Marcus Vinicius Cunha
doaj
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Hoe post-modern is postmodernisme? Enkele gedagtes
Acta Theologica, 1998 It is imperative for the Christian to confront Post-Modernism and try to gauge its meaning(s). The very term Post-Modernism seems to breathe the fresh eschatological air of being 'with it' in a super way - past the modern age and in uncharted waters ...
L F Schulze
doaj +1 more source
Sustainable bioplastics manufacturing from renewable sources
FEBS Open Bio, EarlyView.Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto +6 more
wiley +1 more source
Sofística e Retórica no Górgias de Platão
Araucaria, 2020 This essay aims at elucidating the distinction between sophistry and rhetoric in Plato’s Gorgias starting from Socrates’ enigmatic contention that “sophists and rhetors are mixed up in the same area and about the same thing, since they are so close to ...
Daniel R. N. Lopes
doaj
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Competition, Imagery, and Pleasure in Plato’s Republic, 1–9
Plato, 2014 This paper interprets the Republic’s “parallel” imagery of a contest between the lives of the most just and most unjust men as indicating that book 9’s two pleasure arguments are the culmination of the dialogue’s refutation of Thrasymachus’ sophistry ...
Matthew Robinson
doaj +1 more source