Results 271 to 280 of about 3,116,614 (307)

Sorafenib resistance and therapeutic strategies in hepatocellular carcinoma.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal cancers globally. While surgical resection and liver transplantation offer potential cures for early-stage HCC, the majority of patients are diagnosed at advanced stages where such interventions are not viable.
Weijing Zhang, Xuechuan Hong, Yuling Xiao, Hongbo Wang, Xiaodong Zeng   +4 more
semanticscholar   +3 more sources

Mechanisms of Sorafenib Resistance in Hepatocellular Carcinoma.

Clinics and Research in Hepatology and Gastroenterology
Liver cancer is one of the most common and devastating causes of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancers and represents a significant global health issue. There is currently no effective systemic treatment for patients with advanced liver cancer.
Yuan Liang
semanticscholar   +3 more sources

HBx Modulates Drug Resistance of Sorafenib-Resistant Hepatocellular Carcinoma Cells

Discovery Medicine, 2023
Approximately 50% of hepatocellular carcinoma (HCC) arises due to the infection by hepatitis B virus X protein (HBx). Sorafenib, a unique targeted oral kinase inhibitor, is the therapeutic agent of choice for advanced HCC. The mechanism of HBx in drug resistance of sorafenib-resistant HCC cells was evaluated in this study.Employing a stepwise increase ...
Yaping, Liu, Xu, Liu, Miaosha, Luo, Yarui, Li, Hongxia, Li   +4 more
openaire   +2 more sources

RABL2A–CCDC34 Axis Promotes Sorafenib Resistance in Hepatocellular Carcinoma

DNA and Cell Biology, 2021
In this study, we examined the regulatory role of CCDC34 in the sorafenib sensitivity of hepatocellular carcinoma (HCC) and its functional partners. Wide-type Huh7 and Hep3B and induced sorafenib-resistant (SR) Huh7/SR and Hep3B/SR cells were used as in vitro cell models.
Mingxiu Zhou, Xue Chen, Hansong Bai, Yuemei Sun, Zican Zhang, Simin Li, Xiaoshan Wang, Ming Zeng   +7 more
openaire   +2 more sources

DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.

Cancer Research, 2023
The KEAP1-NRF2 axis is the principal regulator of cellular responses to oxidative and electrophilic stressors. NRF2 hyperactivation is frequently observed in many types of cancer and promotes cancer initiation, progression, metastasis, and resistance to ...
Kun Chang, Yingji Chen, Xuanzhi Zhang, Wei Zhang, Ning Xu, Bohan Zeng, Yue Wang, Tao Feng, Bo Dai, Fujiang Xu, Dingwei Ye, Chenji Wang   +11 more
semanticscholar   +1 more source

Sorafenib for hepatocellular carcinoma: potential molecular targets and resistance mechanisms

Journal of Chemotherapy, 2021
Hepatocellular carcinoma (HCC) is the most widespread typical therapy-resistant, unresectable type of malignant solid tumour with a high death rate constituting huge medical concern. Sorafenib is a small molecule oral multi-target kinase potent inhibitor that acts by suppressing/blocking the multiplication of the tumour cells, angiogenesis, and ...
Mandeep, Dahiya, Harish, Dureja
openaire   +2 more sources

SNHG1, interacting with SND1, contributes to sorafenib resistance of liver cancer cells by increasing m6A‐mediated SLC7A11 expression and promoting aerobic glycolysis

Environmental Toxicology, 2023
Aerobic glycolysis plays an important role in multidrug resistance of cancer cells. Here, we screened different expressed lncRNAs associated with sorafenib resistance of liver cancer cells, by intersecting the bioinformatics analyses of TCGA and GEO (the
Rong Li, Shun-le Li, Lin Shen, Junhui Li, Di Zhang, Jinmin Yu, Lan-Xuan Huang, Na Liu, Hongwei Lu, Meng Xu   +9 more
semanticscholar   +1 more source

SPARC stabilizes ApoE to induce cholesterol-dependent invasion and sorafenib resistance in hepatocellular carcinoma.

Cancer Research
Dysregulation of cholesterol homeostasis is implicated in the development and progression of hepatocellular carcinoma (HCC) that is characterized by intrahepatic and early extrahepatic metastasis.
Shan Wan, Quan-Yao He, Yun-Na Yang, Feng Liu, Xue Zhang, Xin Guo, Hui Niu, Yi Wang, Yi-Xuan Liu, Wen-Long Ye, Xiu-Ming Li, Xue-Mei ZhuanSun, Pu Sun, Xiao-Shun He, Guang Hu, K. Breuhahn, Hua Zhao, Guo-Qiang Wu, Hua Wu   +18 more
semanticscholar   +1 more source

Exosomal miR‐93 derived from hepatocellular carcinoma cell promotes the sorafenib resistance of hepatocellular carcinoma through PTEN/PI3K/Akt pathway

Journal of biochemical and molecular toxicology
Exosomal microRNAs (miRNAs) derived from cancer cell is an important regulatory molecule that mediates the formation of tumor drug resistance, but function and mechanisms of exosomal miRNA in sorafenib resistance of hepatocellular carcinoma (HCC) have ...
Yuanpeng Bao, Song Xu, Jun-jing Zhou, Chongyong Zhao, Saimin Dai, Yong Zhang, Min Rao   +6 more
semanticscholar   +1 more source

Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC

Cellular and Molecular Life Sciences
Hepatocellular carcinoma (HCC) is a malignancy that occurs worldwide and is generally associated with poor prognosis. The development of resistance to targeted therapies such as sorafenib is a major challenge in clinical cancer treatment.
Chunli Mo, Weixin You, Yipeng Rao, Zhenping Lin, Shuai Wang, Ting He, Huanming Shen, Xun Li, Rui Zhang, Boan Li   +9 more
semanticscholar   +1 more source