Results 91 to 100 of about 7,954 (203)

Comparative study of hybrid, tri-hybrid and tetra-hybrid nanoparticles in MHD unsteady flow with chemical reaction, activation energy, Soret-Dufour effect and sensitivity analysis over Non-Darcy porous stretching cylinder

Heliyon
Present study investigates influence of Soret-Dufour effects on MHD unsteady flow of a tetra-hybrid nanofluid (Al2O3, Cu, SiO2 and TiO2 with base fluid water) within non-Darcy porous stretching cylinder. Additionally, chemical reaction, activation energy,
Amudhini M, Poulomi De
doaj   +1 more source

Training and validation of an automated algorithm to differentiate no and minimal diabetic retinopathy from more severe stages in wide‐field images

Acta Ophthalmologica, EarlyView.
Abstract Purpose Diabetic retinopathy (DR) is a leading cause of blindness in the working‐age population. Screening is essential to identify and treat sight‐threatening stages prior to irreversible visual loss. This study aimed to train and validate an automated algorithm to identify no or minimal DR, potentially saving resources for specialist ...
Lars Morten Skollerud, Jakob Kristian Andersen, Sebastian Dinesen, Thiusius Rajeeth Savarimuthu, Jakob Grauslund   +4 more
wiley   +1 more source

Afamelanotide improves quality of life and light tolerance in Austrian erythropoietic protoporphyria patients

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Erythropoietic protoporphyria (EPP) is a rare genetic disorder characterized by severe phototoxic reactions that occur within minutes of light exposure. In clinical studies, afamelanotide has been shown to prolong pain‐free sun exposure, improve quality of life, and reduce the frequency and severity of phototoxic reactions ...
Magdalena Seidl‐Philipp, Hanna Schratter, Johanna Auer, Gerold Schwantzer, Maximilian Lammer, Philipp Hinteregger, Ines Vergeiner, Robert Gruber, Peter Wolf, Angelika Hofer   +9 more
wiley   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Soret and Dufour effects on free convective heat and solute transfer in fluid saturated inclined porous cavity

Engineering Science and Technology, an International Journal, 2015
The present problem addresses double diffusive free convection in an inclined square cavity filled with fluid saturated porous medium under the influence of Soret and Dufour effects. The inclined cavity makes an angle with the horizontal plane.
Chandra Shekar Balla, Kishan Naikoti
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes

The FEBS Journal, EarlyView.
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb, Dominik Hörtnagel, Chris Oostenbrink, Paul G. Furtmüller, Stefan Hofbauer   +4 more
wiley   +1 more source

Student–teacher relationships as a mediator of children's education‐linked genetics: results from the Norwegian Mother, Father and Child Cohort Study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Genetic differences are robustly associated with educational outcomes, but how they become linked is poorly understood. A plausible hypothesis, yet to be thoroughly empirically tested, is that the school environment mediates the association. Methods Using structural equation models, we tested whether the student–teacher relationship at age 5
Chloe Austerberry, Elizabeth C. Corfield, Alexandra Havdahl, Dinka Smajlagic, Ragnhild Eek Brandlistuen, Mari Vaage Wang, Laurel Fish, Marialivia Bernardi, Jessica van de Grint‐Stoop, Mona Bekkhus, Pasco Fearon   +10 more
wiley   +1 more source

Subduction Initiation and Early Subduction Zone Development: Insights From the P–T–t Path of the Bay of Islands Metamorphic Sole

Journal of Metamorphic Geology, EarlyView.
ABSTRACT The processes involved during subduction initiation (SI) remain poorly constrained, in part due to the rarity of geological archives. Ophiolites and their underlying metamorphic soles are thought to form during subduction zone infancy and may thus provide critical constraints. Metamorphic soles are derived from oceanic crust of the lower plate
François Fournier‐Roy, Carl Guilmette, Mark Coleman, Kyle Larson, Douglas K. Tinkham, Alana M. Hinchey, John Wakabayashi, Jean H. Bédard, Louise Mérit, Philippe Agard, Loïc Labrousse, Antoine Godet   +11 more
wiley   +1 more source

Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model

Photochemistry and Photobiology, EarlyView.
Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore, Brian Schnoor, Kathryn L. McNaughton, Idrisa Rahman, Benjamin D. Powers, Dana M. Roque, Huang‐Chiao Huang   +6 more
wiley   +1 more source