Results 111 to 120 of about 331,221 (286)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Outcomes of carboplatin-paclitaxel induction chemotherapy followed by chemoradiotherapy in locally advanced oropharyngeal and hypopharyngeal cancer: A retrospective study in a resource-limited setting

Cancer Research, Statistics, and Treatment
Background: The role of induction chemotherapy (ICT) in locally advanced oropharyngeal and hypopharyngeal squamous cell carcinoma (SCC) remains debated, particularly in resource-limited settings.
Subramanian Vijayakanth, Tapkire Ritesh, Karpurmath Shashidhar, Kesavan Niraimathi, Soundappan Kathirvel, Malik Kapil, Talagadadeevi Bharath, Kannan Ravi   +7 more
doaj   +1 more source

Can we apply accelerator-cores to control-intensive programs? [PDF]

, 2009
There is a trend towards using accelerators to increase performance and energy efficiency of general-purpose processors. So far, most accelerators have been build with HPC-applications in mind.
De Bosschere, Koen, Rul, Sean, Vandierendonck, Hans   +2 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Neglected Tropical Diseases: responding to calls for action from the front lines in Ethiopia

Journal of Infection in Developing Countries, 2020
Ebba Abate, John C Reeder
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Role of triage audit in an ongoing differentiated TB care initiative to reduce deaths in Tamil Nadu, India

Public Health Action
OBJECTIVE: In the ongoing India’s first state-wide differentiated TB care programme in Tamil Nadu (TN-KET), adults diagnosed with drug-sensitive TB at public facilities undergo triage.
A. Jeyakumar, S. Kalaiselvi, D. Nair, R. Vijayaprabha, D. Kabir, J.M. Melfha, T. Bhatnagar, R. Srinivasan, K. Gayathri, K. Boopathi, R.S. Vaman, V. Rajan, S. Shanmugasundaram, A. Frederick, H.D. Shewade   +14 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source