Results 171 to 180 of about 30,121,245 (253)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The adaptive landscapes of three global <i>Escherichia coli</i> transcriptional regulators. [PDF]

Elife
Westmann CA, Goldbach L, Wagner A.
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A nationwide study of community- versus facility-based management of malaria in Sierra Leone from 2019 to 2023. [PDF]

Public Health Action
Sillah-Kanu M, Kamara D, Kamara IF, Fofanah BD, Fiona OO, Vandy AO, Kamara ARY, Lahai WK, Owusu H, Zachariah R, Ramsay A, Falama AM, Sesay MA, Lakoh S, Kanu MS, Tejan YS, SorieTuray I, Thomas F, Squire JS.   +18 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Treatment for Hyperosmolar Dehydration in Hospitalised Adults: Protocol for a Scoping Review of Current Evidence and Gaps. [PDF]

JMIR Res Protoc
Hansen CH, Mortensen LT, Brandstrup B, Beck AM, Andersen S, Danielsen MB.   +5 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

'So, this feels very different and, you know, kindly': a mixed methods study of arts on prescription in secondary care. [PDF]

Eur J Public Health
Holt NJ, Baber D, Elliott C.
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Corona-Driven Microdroplet Coalescence on an Open Oil Film with Intelligent Detection and Tracking. [PDF]

Micromachines (Basel)
Qiu X, Cui X, Liu Y, Liu H, Cheng B, Zhang J, Tang Q.   +6 more
europepmc   +1 more source