Results 141 to 150 of about 379,550 (314)

Adapting the Structured Operational Research Training Initiative (SORT IT) for high-income countries

, 2019
SORT IT (Structured Operational Research Training InitiaTive) is a successful capacity building programme started 10 years ago to develop operational research skills in low- and middle-income countries. Public Health England (PHE) aims to embed a culture
Cleary, P, Wilkinson, E, Harries, AD, Kliner, M, Smith, K, Stewart, A, Ghebrehewet, S   +6 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Viral load testing coverage and suppression rate among children and adolescents on ART in Sierra Leone

Public Health Action
SETTING: Anti-retroviral treatment (ART) centres from eight districts of Sierra Leone. OBJECTIVES: Among children and adolescents (0–19 years) registered for ART after January 2023 and currently on care, to assess i) viral load (VL) testing coverage and ...
F. Kanu, F. Lansana, M. Mustapha, E.K. Tabor, P. Thekkur, I.F. Kamara, B.D. Fofanah, J.S. Kanu, N. Sesay, I.S. Turay, J.A. Koroma, W.K. Lahai, A.M. Falama, M.A. Sesay, S. Lakoh   +14 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

FastSort: An External Sort Using . . .

, 1986
FastSort is an external sort that uses parallel processing, large main memories and parallel disc accesses to obtain high performance. FastSort can sort a file as quickly as it can read the input and it can produce the result as quickly as it can write ...
Susan Uren, Michael Stewart, Alex Tsukerman, Bonnie Vaughan, Jim Gray   +4 more
core  

Solid State Drives And The Sort-Merge

, 2016
This paper discusses the history of the sort-merge routine and the impacts of hardware limitations on the performance of sort-merge processing.  The results of comparing a single-step sort-merge with a two-step sort-merge in a hard-disk drive (HDD ...
Haworth, Dwight A.
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Teknik Selection Sort dan Bubble Sort Menggunakan Borland C++

, 2018
Abstrak: Peran algoritma dalam perangkat lunak atau pemograman begitu penting, sehingga perlu memahami konsep dasar algoritma. Hampir setiap saat dalam kehidupan sehari - hari sering dijumpai permasalahan - permasalahan yang harus diselesaikan dengan ...
Khasanah, Fata Nidaul, Saputro, Fauzi Eko, admin, admin   +2 more
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Point-of-care diagnostics for sexually transmitted infections among migrants in Greece

Public Health Action
SETTING: Sexually transmitted infections (STIs) can impact individuals of any demographic. The most common pathogens causing STIs are Chlamydia trachomatis, Neisseria gonorrhea and Trichomonas vaginalis; these can be treated with specific antibiotics ...
C. Tsorou, A. Williams, W. van den Boogaard, N. Staderini, E. Repetto, A. Terzidis, E. Pikoulis   +6 more
doaj   +1 more source