Results 201 to 210 of about 379,550 (314)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Performance evaluation of GPU-based parallel sorting algorithms. [PDF]

PLoS One
Ala'anzy MA, Tolendi N, Baubek B, Algarni A.   +3 more
europepmc   +1 more source

It was nice because citizenship was sort of in the group itself

, 2007
Watt, P., Gifford, C., Clark, W., Koster, S.   +3 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Exploring meaning in culture: Insights from meaning-centered psychotherapy in Aotearoa, New Zealand. [PDF]

Palliat Support Care
Clayden C, Wells A, Applebaum AJ, Reynolds L.   +3 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Mapping malaria hotspots through spatial and spatio-temporal analysis in Sierra Leone, 2021-2024. [PDF]

Public Health Action
Falama AM, Omoniwa O, Kanu MS, Lahai WK, Kamara ARY, Ameh G, Kamara IF, Fofanah BD, Kenneh S, Kamara MN, Sesay MA, Sesay N, Kanu F, Alwani AA, Thekkur P, Zachariah R, Kanu MS, Lakoh S.   +17 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Heated Tobacco Products: Current Evidence of Pulmonary Harm and Lung Cancer Risk. [PDF]

Cureus
Albuquerque BL, Coelho IM, Albuquerque IL, Lanhas H, Vilaça AF.   +4 more
europepmc   +1 more source

A case study exploration of primary teachers' conceptions of whole class interactive mathematics teaching

Research has shown, with respect to the learning of mathematics, that whole class interactive teaching, its form and function, is a complex phenomenon.
Sayers, Judy
core