Results 161 to 170 of about 6,219 (205)
Editorial: Functional neuroendocrine tumors. [PDF]
Front Endocrinol (Lausanne)Popovic B +3 more
europepmc +1 more source
The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases. [PDF]
Mol NeurodegenerTakahashi H, Strittmatter SM.
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Dimerization of sortilin regulates its trafficking to extracellular vesicles
Journal of Biological Chemistry, 2018 Extracellular vesicles (EVs) play a critical role in intercellular communication by transferring microRNAs, lipids, and proteins to neighboring cells. Sortilin, a sorting receptor that directs target proteins to the secretory or endocytic compartments of
Elena Aikawa, Masanori Aikawa
exaly +2 more sources
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Sortilin turnover is mediated by ubiquitination
Biochemical and Biophysical Research Communications, 2013Sortilin is a transmembrane domain protein that has been implicated in the sorting of prosaposin and other soluble cargo from the Golgi to the lysosomal compartment. While the majority of the receptor is recycled back to the Golgi from endosomes, it is known that upon successive rounds of transport, a proportion of sortilin is degraded in lysosomes ...
Stéphane Lefrançois
exaly +3 more sources
Sortilins in Neurotrophic Factor Signaling
2014The sortilin family of Vps10p-domain receptors includes sortilin, SorLA, and SorCS1-3. These type-I transmembrane receptors predominate in distinct neuronal tissues, but expression is also present in certain specialized non-neuronal cell populations including hepatocytes and cells of the immune system.
Glerup, S +2 more
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Role of sortilin in lipid metabolism
Current Opinion in Lipidology, 2019Purpose of review Sortilin, encoded SORT1 gene at chromosome 1p13.3, is a multiligand receptor that traffics protein from the Golgi to the endosomes, secretory vesicles, and the cell surface. Genome-wide association studies (GWAS) revealed an association between sortilin and reduced plasma LDL-cholesterol (LDL-C) as well as ...
openaire +2 more sources
Cardiology in Review, 2014
Hyperlipidemia is an important risk factor for cardiovascular disease globally, but there is still much mystery surrounding the topic of lipid regulation. Many studies have attempted to assess the underlying genetic basis of low-density lipoprotein (LDL) metabolism.
Adarsh M, Thaker, William H, Frishman
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Hyperlipidemia is an important risk factor for cardiovascular disease globally, but there is still much mystery surrounding the topic of lipid regulation. Many studies have attempted to assess the underlying genetic basis of low-density lipoprotein (LDL) metabolism.
Adarsh M, Thaker, William H, Frishman
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ProNGF, Sortilin, and Age‐related Neurodegeneration
Annals of the New York Academy of Sciences, 2007Abstract: Several studies have sought to demonstrate that neurodegeneration during disease and in old age is associated with reduced neurotrophic support. Little positive evidence has been forthcoming, either in relation to the availability of neurotrophins or to expression and function of the relevant receptors.
Raya, Al-Shawi +7 more
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Sortilins: new players in lipoprotein metabolism
Current Opinion in Lipidology, 2011Sortilins are sorting receptors that direct proteins through secretory and endocytic pathways of the cell. Previously, these receptors have been shown to play important roles in regulating protein transport in neurons and to control neuronal viability and death in many diseases of the nervous system.
Thomas E, Willnow +2 more
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