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The Interaction Between Progranulin with Sortilin and the Lysosome
2018Accumulating evidence suggests that progranulin is essential for proper lysosomal function. Progranulin is a lysosomal resident protein and sortilin has been demonstrated to be the lysosomal trafficking receptor for progranulin. Here we describe the methods used to study the interaction between progranulin and sortilin, as well as the critical role of ...
Xiaolai, Zhou +3 more
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Sortilin in microglia reactivity
2017Neuropathic pain is a serious neurological disease estimated to affect around 8% of the Western population. It can be caused by either direct injuries to the peripheral nervous system (e.g. surgery) or indirect injuries (e.g. diabetes or cancer). Unfortunately, patients very often do not respond to, experience severe side effects or become resistant to
Svenningsen, Anne Louise Søby; id_orcid 0009-0006-1087-6542 +5 more
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Sortilin Weighs In on the Side of Death
Science's STKE, 2004Nerve growth factor (NGF) and its precursor proNGF bind to receptors on neurons to promote cell survival, differentiation, or death (see Kaplan and Miller). Two classes of receptors that interact with NGF or proNGF are members of the Trk family and p75 NTR .
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2016
Neuropathic pain is a serious neurological disease affecting patients with peripheral nerve injuries and neuropathies. Unfortunately, the existing treatments are insufficient in giving patients pain relieve and preventing the development of neuropathic pain.Neuroinflammation is a major contributing factor in the development of neuropathic pain.
Svenningsen, Anne Louise Søby; id_orcid 0009-0006-1087-6542 +5 more
openaire +1 more source
Neuropathic pain is a serious neurological disease affecting patients with peripheral nerve injuries and neuropathies. Unfortunately, the existing treatments are insufficient in giving patients pain relieve and preventing the development of neuropathic pain.Neuroinflammation is a major contributing factor in the development of neuropathic pain.
Svenningsen, Anne Louise Søby; id_orcid 0009-0006-1087-6542 +5 more
openaire +1 more source
The multifaceted role of sortilin/neurotensin receptor 3 in human cancer development
Journal of Cellular Physiology, 2021Kioomars Saliminejad +2 more
exaly
Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin
Brain Communications, 2022Xiaolai Zhou +2 more
exaly
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation
Frontiers in Neuroscience, 2020Shuji Sato, Akito Hata, Hisao Shimizu
exaly