ABSTRACT Introduction Politicized cyber shaming recodes adolescents' cultural interests as evidence of political loyalty or moral belonging. This study examines how such shaming is associated with longer‐term identity tension in adolescence, focusing on public expression, peer belonging, and self‐evaluation after politicized online controversy ...
Linsen Yang
wiley +1 more source
Conservation genomics within government led conservation planning: an Australian case study exploring cost and benefit for threatened flora. [PDF]
Doyle CAT +10 more
europepmc +1 more source
ABSTRACT Mechanistic PK/PD models represent complex biological systems in which model parameters are in nonlinear, multidimensional parameter spaces and often require robust optimization informed by experimental data, making parameter estimation a critical yet challenging aspect of pharmacometric analysis.
Dongjin Lee, Chih‐Wei Lin
wiley +1 more source
Loss of DNA mismatch repair genes leads to acquisition of antibiotic resistance independent of secondary mutations. [PDF]
Bautista DE +4 more
europepmc +1 more source
Application of Systems Genetics to Investigate Molecular Pathology of Early‐Onset Colorectal Cancer
Early‐onset colorectal cancer (EOCRC) presents a complex molecular landscape that requires integrated multi‐omics approaches. This article reviews current applications of systems genetics in EOCRC research and provides a step‐by‐step protocol for network‐based analyses featuring PIK3CA to demonstrate practical application for researchers of all levels.
Minjae J. Kim +3 more
wiley +1 more source
An RNA splicing system that excises DNA transposons from animal mRNAs. [PDF]
Zhao LW +5 more
europepmc +1 more source
ABSTRACT Assessing genetic diversity is essential for conserving endangered populations, yet comprehensive genomic evaluations remain limited for many declining species. Here, we investigated inbreeding levels and effective population sizes (Ne) of caribou (Rangifer tarandus) in western Canada, where populations have experienced pronounced declines ...
Charlotte Bourbon +11 more
wiley +1 more source
High-throughput screening reveals diverse lambdoid prophage inducers. [PDF]
Nair G, Fatima R, Hynes AP.
europepmc +1 more source
The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova +12 more
wiley +1 more source
Prophages and their interactions with lytic phages in the human gut microbiota and their impact on microbial diversity, gut health, and disease. [PDF]
Zhang S +5 more
europepmc +1 more source

