Results 101 to 110 of about 72,292 (263)

Cardiotoxicity of BRAF/MEK inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe   +4 more
wiley   +1 more source

Engaging Children With Disabilities in Family Life Research Through Inclusive and Visually Supported Workshops

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT This article presents a methodological study examining how inclusive, visually supported workshops can facilitate the participation of children with disabilities in research on family life. The study demonstrates how the combined use of visual structuring, sensory‐aware pacing and relational scaffolding can expand communicative possibilities ...
Cecilie K. Moesby‐Jensen   +1 more
wiley   +1 more source

Examining Policies and Practices to Support Young People Transitioning From Out‐of‐Home Care (OOHC) in Asia: What Do We Know From Existing Grey Literature?

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT Young people transitioning from out‐of‐home care, also known as care leavers, are globally recognised as a vulnerable group. There is a scarcity of literature on leaving care across the Global South, including Asia. The authors examined policies and practices from the grey literature to gain insights from broader literature beyond peer ...
Rangga Radityaputra   +2 more
wiley   +1 more source

Building Trust in the First Stages of Research With Children

open access: yesChildren &Society, EarlyView.
ABSTRACT This article focuses on the process of building trust in the first stages of research with children. Based on three research examples conducted in Finland, we analyse the ways of building trust and illustrate how trust or distrust can emerge in research with children.
Terhi Tuukkanen, Elina Weckström
wiley   +1 more source

DinB Upregulation Is the Sole Role of the SOS Response in Stress-Induced Mutagenesis in Escherichia coli

open access: yesGenetics, 2009
R. Galhardo   +6 more
semanticscholar   +1 more source

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese   +12 more
wiley   +1 more source

Exploring plant tolerance to biotic and abiotic stresses [PDF]

open access: yes, 2007
Plants are exposed to many stress factors, such as drought, high salinity or pathogens, which reduce the yield of the cultivated plants or affect the quality of the harvested products. Arabidopsis thaliana was used as a model plant to study the responses
Karim, Sazzad
core  

Targeting the Menin–KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Acute leukemias characterized by a shared epigenetic dependency on the menin–KMT2A axis rely on aberrant HOX‐driven transcriptional programs that sustain leukemic self‐renewal and impair differentiation. This dependency is most evident in KMT2A‐rearranged and NPM1‐mutated acute myeloid leukemia (AML), but also extends to other HOX‐dependent ...
Antonella Bruzzese   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy