Results 11 to 20 of about 6,971 (209)

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Lethal and mutagenic properties of MMS-generated DNA lesions in Escherichia coli cells deficient in BER and AlkB-directed DNA repair. [PDF]

, 2010
Methylmethane sulphonate (MMS), an S(N)2-type alkylating agent, generates DNA methylated bases exhibiting cytotoxic and mutagenic properties. Such damaged bases can be removed by a system of base excision repair (BER) and by oxidative DNA demethylation ...
Sikora, Anna, Grzesiuk, Elzbieta, A. Sikora, J. Nieminuszczy, Mielecki, Damian, D. Mielecki, A. Chojnacka, Nieminuszczy, Jadwiga, Wrzesiński, Michał, M. Wrzesinski, E. Grzesiuk, Chojnacka, Aleksandra   +11 more
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Mutagenic potency of MMS-induced 1meA/3meC lesions in E. coli. [PDF]

, 2009
The mutagenic activity of MMS in E. coli depends on the susceptibility of DNA bases to methylation and their repair by cellular defense systems. Among the lesions in methylated DNA is 1meA/3meC, which is recently recognized as being mutagenic.
Janion, Celina, Jadwiga Nieminuszczy, Sikora, Anna, Joanna Krwawicz, Mielecki, Damian, Wrzesiński, Michał, MichaÅ WrzesinÌski, Celina Janion, Krwawicz, Joanna, Grzesiuk, Elzbieta, Anna Sikora, ElzÌbieta Grzesiuk, Nieminuszczy, Jadwiga, Damian Mielecki, Aleksandra Chojnacka, Chojnacka, Aleksandra   +15 more
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Inotuzumab ozogamicin as single agent in pediatric patients with relapsed and refractory acute lymphoblastic leukemia: results from a phase II trial [PDF]

, 2022
Inotuzumab Ozogamicin is a CD22-directed antibody conjugated to calicheamicin, approved in adults with relapsed or refractory (R/R) B cell acute lymphoblastic leukemia (BCP-ALL).
Plat, Geneviève, Locatelli, Franco, Pennesi, Edoardo, Bautista Sirvent, Francisco J., Rialland, Fanny, Von Stackelberg, Arend, Chen, Ying, Boer, Judith M., Rizzari, Carmelo, Reinhardt, Dirk, Zwaan, Christian M., Ammerlaan, Anneke J.C., Ammerlaan, Anneke J. C., van der Velden, Vincent H.J., Bertrand, Yves, Petit, Arnaud, Rives, Susana, Vormoor-Bürger, Britta, van der Velden, Vincent H. J., Bielorai, Bella, Chen-Santel, Christiane, Vinti, Luciana, Rössig, Claudia, Engstler, Gernot, Bruno, Benedicte, Michels, Naomi, Brivio, Erica, Jiang, Yilin, Sleight, Barbara, Starý, Jan, Beverloo, H. Berna, Thano, Adriana   +31 more
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Influence of the Escherichia coli oxyR gene function on lambda prophage maintenance [PDF]

, 2010
In Escherichia coli hosts, hydrogen peroxide is one of the factors that may cause induction of lambda prophage. Here, we demonstrate that H2O2-mediated lambda prophage induction is signiWcantly enhanced in the oxyR mutant host. The mRNA levels for cI
Łoś, Marcin, Anna Herman-Antosiewicz, Grzegorz Węgrzyn, Wróbel, Borys, Węgrzyn, Alicja, Szambowska, Anna, Łoś, Joanna, Joanna Całkiewicz, Agata Czyż, Borys Wróbel, Herman-Antosiewicz, Anna, Marcin Łoś, Całkiewicz, Joanna, Joanna M. Łoś, Anna Szambowska, Glinkowska, Monika, Czyż, Agata, Węgrzyn, Grzegorz, Alicja Węgrzyn, Monika Glinkowska   +19 more
core   +1 more source

Prosecutor: parameter-free inference of gene function for prokaryotes using DNA microarray data, genomic context and multiple gene annotation sources [PDF]

, 2008
Background: Despite a plethora of functional genomic efforts, the function of many genes in sequenced genomes remains unknown. The increasing amount of microarray data for many species allows employing the guilt-by-association principle to predict ...
Hofstede, K.J., Oscar P Kuipers, Hijum, Sacha A.F.T. van,, Breitling, Rainer, Blom, E.J., Breitling, R., Breitling, Rainer,, Blom Evert, Roerdink, J.B.T.M., Hofstede Klaas, Breitling Rainer, Jos BTM Roerdink, Blom, Evert Jan, Klaas Hofstede, Roerdink, J.B.T.M.; id_orcid, Kuipers, Oscar P.,, van Hijum, S.A F T, Kuipers, O.P., Hofstede, Klaas Jan,, Roerdink, Jos B T M, van Hijum Sacha AFT, Roerdink Jos BTM, Kuipers, Oscar P., Rainer Breitling, van Hijum, S.A.F.T., Kuipers Oscar P, Hofstede, Klaas Jan, van Hijum, Sacha A F T, Blom, Evert Jan,, Sacha AFT van Hijum, Roerdink, Jos B.T.M.,, Evert Blom, Kuipers, O.P.; id_orcid   +32 more
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AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Identification of a Novel Streptococcal Gene Cassette Mediating SOS Mutagenesis in Streptococcus uberis [PDF]

, 2007
Streptococci have been considered to lack the classical SOS response, defined by increased mutation after UV exposure and regulation by LexA. Here we report the identification of a potential self-regulated SOS mutagenesis gene cassette in the ...
E. Varhimo, Varhimo, Emilia,, Kuipers, Oscar P.; id_orcid, J. Jalava, Kuipers, Oscar P., Varmanen, Pekka, Savijoki, Kirsi,, Varhimo, Emilia, P. Varmanen, K. Savijoki, Jalava, Jari, Kuipers, Oscar P.,, Varmanen, Pekka,, O. P. Kuipers, Jalava, Jari,, Savijoki, Kirsi   +15 more
core   +1 more source

Empowering and conquering infirmity of visually impaired using AI‐technology equipped with object detection and real‐time voice feedback system in healthcare application

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract The Internet of Things is emerging as a crucial technology in aiding humans and making their lives easier. Among the human population, a large percentage of people suffer from disabilities resulting in challenges in everyday life particularly people with visual disabilities.
Hania Tarik, Shahzad Hassan, Rizwan Ali Naqvi, Saddaf Rubab, Usman Tariq, Monia Hamdi, Hela Elmannai, Ye Jin Kim, Jae‐Hyuk Cha   +8 more
wiley   +1 more source

The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus

, 2011
Objectives The antistaphylococcal pyrrolobenzodiazepine dimer ELB-21 forms multiple adducts with duplex DNA through covalent interactions with appropriately spaced guanine residues; it is now known to form interstrand and intrastrand adducts with ...
Rahman, Khondaker; id_orcid, Thurston, DE, Taylor, PW, Feuerbaum, EA, Helena Rosado, David E. Thurston, Rahman, KM, Peter W. Taylor, Rosado, H, Hinds, J, Khondaker M. Rahman, Jason Hinds, Eva-Anne Feuerbaum   +12 more
core   +1 more source