Results 11 to 20 of about 72,292 (263)

Sending out an SOS - the bacterial DNA damage response

Genetics and Molecular Biology, 2022
The term “SOS response” was first coined by Radman in 1974, in an intellectual effort to put together the data suggestive of a concerted gene expression program in cells undergoing DNA damage.
Marco A Lima-Noronha, D. Fonseca, Renatta S Oliveira, Rúbia R Freitas, Jung H Park, R. Galhardo   +5 more
semanticscholar   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin

PLoS Genetics, 2013
High levels of antibiotic tolerance are a hallmark of bacterial biofilms. In contrast to well-characterized inherited antibiotic resistance, molecular mechanisms leading to reversible and transient antibiotic tolerance displayed by biofilm bacteria are ...
Steve P. Bernier, D. Lebeaux, Alicia S. DeFrancesco, A. Valomon, G. Soubigou, J. Coppee, J. Ghigo, C. Beloin   +7 more
semanticscholar   +1 more source

Contribution of SOS genes to H2O2-induced apoptosis-like death in Escherichia coli

Current Genetics, 2021
Hydrogen peroxide (H2O2) is a debriding agent that damages the microbial structure and function by generating various reactive oxygen species (ROS). H2O2-produced hydroxyl radical (OH∙) also exerts oxidative stress on microorganisms.
Heesu Kim, D. G. Lee
semanticscholar   +1 more source

SOS Response Induces Persistence to Fluoroquinolones in Escherichia coli

PLoS Genetics, 2009
Bacteria can survive antibiotic treatment without acquiring heritable antibiotic resistance. We investigated persistence to the fluoroquinolone ciprofloxacin in Escherichia coli.
Tobias Dörr, K. Lewis, M. Vulić
semanticscholar   +1 more source

Separation of Recombination and SOS Response in Escherichia coli RecA Suggests LexA Interaction Sites

PLoS Genetics, 2011
RecA plays a key role in homologous recombination, the induction of the DNA damage response through LexA cleavage and the activity of error-prone polymerase in Escherichia coli.
Anbu K. Adikesavan, Panagiotis Katsonis, D. Marciano, R. Lua, C. Herman, O. Lichtarge   +5 more
semanticscholar   +1 more source

Conjugative DNA Transfer Induces the Bacterial SOS Response and Promotes Antibiotic Resistance Development through Integron Activation

PLoS Genetics, 2010
Conjugation is one mechanism for intra- and inter-species horizontal gene transfer among bacteria. Conjugative elements have been instrumental in many bacterial species to face the threat of antibiotics, by allowing them to evolve and adapt to these ...
Z. Baharoglu, David Bikard, D. Mazel
semanticscholar   +1 more source

Role of RecA and the SOS Response in Thymineless Death in Escherichia coli

PLoS Genetics, 2010
Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when deprived of thymine.
N. C. Fonville, D. Bates, P. Hastings, P. Hanawalt, S. Rosenberg   +4 more
semanticscholar   +1 more source

The Sulfolobus solfataricus radA paralogue sso0777 is DNA damage inducible and positively regulated by the Sta1 protein [PDF]

, 2007
Little is known about the regulation of the DNA damage-mediated gene expression in archaea. Here we report that the addition of actinomycin D to Sulfolobus solfataricus cultures triggers the expression of the radA paralogue sso0777.
Abella, M, Barbe, J, Campoy, S, Paytubi, S, Rodriquez, S, White, Malcolm Frederick   +5 more
core   +1 more source

Response perseveration and the triarchic model of psychopathy in an undergraduate sample. [PDF]

, 2020
This study aimed to extend previously reported links between distinctive configurations of traits in the psychopathic personality and maladaptive response perseveration, by examining performance in the Card Perseveration Task (CPT) within the ...
Branchadell, Victoria, Molto, Javier, Poy, Rosario, Ribes Guardiola, Pablo, Segarra, Pilar   +4 more
core   +1 more source