Results 81 to 90 of about 6,630,130 (315)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The usability of open source software: analysis and prospects

open access: yes, 2006
Open source communities have successfully developed many pieces of software although most computer users only use proprietary applications. The usability of open source software is often regarded as one reason for this limited distribution. In this paper
Nichols, David M., Twidale, Michael B.
core  

Source-side syntactic reordering patterns with functional words for improved phrase-based SMT [PDF]

open access: yes, 2010
Inspired by previous source-side syntactic reordering methods for SMT, this paper focuses on using automatically learned syntactic reordering patterns with functional words which indicate structural reorderings between the source and target language ...
Jie Jiang   +5 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Other title: Source water assessment Other title: Index of potential drinking water contamination sources

open access: yes, 2000
"June 8, 2000."; application/pdfThe 1996 amendments to the Safe Drinking Water Act require that all states develop a source water assessment plan and that source water assessments be prepared for all public drinking water systems within the state.
Kansas. Nonpoint Source Section.
core  

Open source software and libraries [PDF]

open access: yes, 2008
Open source software is, software that users have the ability to run, copy, distribute, study, change, share and improve for any purpose. Open source library software’s does not need the initial cost of commercial software and enables libraries to have ...
Randhawa, Sukhwinder
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

ENA Source Attribute Helper

open access: yes, 2022
ENA Source Attribute Helper: An Application Programming Interface to facilitate accurate reference to biological source ...
Suran Jayathilaka, Vikas Gupta
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Open Source for Digital Curation [PDF]

open access: yes, 2005
This Curation Manual instalment discusses at some lengths the relevant strengths of open source software from a digital curation perspective, as well as detailing some of its more general advantages, which must be understood in order to accept the ...
McHugh, Mr Andrew, McHugh, Andrew
core  

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