Results 51 to 60 of about 729,783 (267)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The likelihood encoder for source coding [PDF]
2013 IEEE Information Theory Workshop (ITW), 2013 The likelihood encoder with a random codebook is demonstrated as an effective tool for source coding. Coupled with a soft covering lemma (associated with channel resolvability), likelihood encoders yield simple achievability proofs for known results, such as rate-distortion theory.
Paul Cuff, Eva C. Song
openaire +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
ComputersIn higher education, especially in programming-intensive fields like computer science, safeguarding students’ source code is crucial to prevent theft that could impact learning and future careers.
Leonardo Juan Ramirez Lopez +1 more
doaj +1 more source
Analog coding of a source with erasures [PDF]
2016 IEEE International Symposium on Information Theory (ISIT), 2016 Analog coding decouples the tasks of protecting against erasures and noise. For erasure correction, it creates an "analog redundancy" by means of band-limited discrete Fourier transform (DFT) interpolation, or more generally, by an over-complete expansion based on a frame.
Marina Haikin, Ram Zamir
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On locally decodable source coding [PDF]
2015 IEEE International Conference on Communications (ICC), 2015 Locally decodable channel codes form a special class of error-correcting codes with the property that the decoder is able to reconstruct any bit of the input message from querying only a few bits of a noisy codeword. It is well known that such codes require significantly more redundancy (in particular have vanishing rate) compared to their non-local ...
Makhdoumi, Ali +3 more
openaire +3 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A Novel Method for Code Clone Detection Based on Minimally Random Kernel Convolutional Transform
IEEE AccessEffectively detecting code clones is essential for maintaining and evolving software systems. This paper introduces a novel approach that leverages minimally random kernel convolutional transform (MiniRocket) to represent source code for clone detection.
Mostefai Abdelkader
doaj +1 more source