Results 81 to 90 of about 16,051,352 (293)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Influence of spatial variation in daily rainfall on volume capture of rainfall by source control facilities in China

Shui kexue jinzhan, 2018
In order to study the influences of rainfall characteristics on the effectiveness of total runoff capture in different regions of China, the study draws on the daily precipitation data of 186 meteorological stations over nearly three decades for spatial ...
ZHANG Zhiming, HU Beibei, LI Junqi, WANG Wenliang, WANG Sisi   +4 more
doaj   +1 more source

CONTRACTING FOR NONPOINT-SOURCE POLLUTION ABATEMENT [PDF]

This study presents an incentive scheme to control agricultural nonpoint-source pollution. The analysis is based on a principal-agent framework with two parties: farmers and a regulating authority.
Bystrom, Olof, Bromley, Daniel W.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Mechanisms of Ofloxacin Exposure Inhibiting Hydrogen Production in Anaerobic Fermentation

Fermentation
Ofloxacin (OFL) exists widely in raw materials of organic fermentation, which can inhibit hydrogen production of dark fermentation. In this study, the inhibition of OFL on hydrogen production was studied from the aspects of hydrogen production ...
Luyao Zhou, Jiasheng Zhang, Jianning Chang, Panyue Zhang   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Robust and fast sliding-mode control for a DC-DC current-source parallel-resonant converter [PDF]

, 2018
Modern DC-DC resonant converters are normally built around a voltage-source series-resonant converter. This study aims to facilitate the practical use of current-source parallel-resonant converters due to their outstanding properties.
García de Vicuña Muñoz de la Nava, José Luis, Mohammad Moradi Ghahderijani, Momeneh, Arash, Miguel Castilla, Moradi Ghahderijani, Mohammad, Miret Tomàs, Jaume, Luis García de Vicuña, Castilla Fernández, Miguel, Arash Momeneh, Jaume Miret   +9 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source