Results 71 to 80 of about 7,549,002 (298)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Dynamically Decoding Source Domain Knowledge for Domain Generalization
CoRR, 2021 Optimizing the performance of classifiers on samples from unseen domains remains a challenging problem. While most existing studies on domain generalization focus on learning domain-invariant feature representations, multi-expert frameworks have been proposed as a possible solution and have demonstrated promising performance.
Cuicui Kang, Karthik Nandakumar
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Music Source Separation in the Waveform Domain
CoRR, 2019 Source separation for music is the task of isolating contributions, or stems, from different instruments recorded individually and arranged together to form a song. Such components include voice, bass, drums and any other accompaniments.Contrarily to many audio synthesis tasks where the best performances are achieved by models that directly generate ...
Défossez, Alexandre +3 more
openaire +4 more sources
Metaphorization origins: Key points. Translation and comments by L.V. Kalashnikova [PDF]
Актуальные проблемы филологии и педагогической лингвистикиThe essence of metaphor’s reliance on two domains, a source and a target, is argued as stemming from a fundamental characteristic of higher cognition—that of conceptualizing more than one cognitive/embodied domain at the same time. This cognitive duality
Herbert L. Colston
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Research Perspectives on the Public Domain [PDF]
, 2014 This document presents an edited transcript of the one-day event, ‘Research Perspectives on the Public Domain’, held at the University of Glasgow on 11thOctober, 2013.
Erickson, Kristofer, Kretschmer, Martin
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Take a trip down memory lane : une approche contrastive des métaphores de la mémoire
Lexis: Journal in English LexicologyThe aim of this paper is to identify the various source domains at work in memory metaphors in the English language. Setting the results of a qualitative and contrastive approach based on an empirical collection of memory metaphors against those from a ...
Rémi Digonnet
doaj +1 more source