Results 81 to 90 of about 980,863 (293)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Source localization using acoustic vector sensors: a music approach [PDF]

, 2009
Traditionally, a large array of microphones is used to localize multiple far field sources in acoustics. We present a sound source localization technique that requires far less channels and measurement locations (affecting data channels, setup times and ...
Bree, Hans-Elias de, Tijs, Emiel, Wind, Jelmer W.   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Theoretical and experimental study on time-domain monopole time reversal method with excluding autocorrelation

AIP Advances
Monopole time reversal is an advanced noise source localization technique, but its sidelobe level in localizing sound sources is greatly affected by noise, leading to a decrease in the accuracy of sound source localization under a low signal-to-noise ...
Mingxin Geng, Chen Shen, Jiangang Ma, Xiaolong Wei, Lv Wang, Yalin Zhao   +5 more
doaj   +1 more source

Electrical source localization by LORETA in patients with epilepsy: Confirmation by postoperative MRI

Annals of Indian Academy of Neurology, 2016
Background: Few studies have been conducted that have compared electrical source localization (ESL) results obtained by analyzing ictal patterns in scalp electroencephalogram (EEG) with the brain areas that are found to be responsible for seizures using ...
Gülsüm Akdeniz
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dynamic Responses in Brain Networks to Social Feedback: A Dual EEG Acquisition Study in Adolescent Couples

Frontiers in Computational Neuroscience, 2017
Adolescence is a sensitive period for the development of romantic relationships. During this period the maturation of frontolimbic networks is particularly important for the capacity to regulate emotional experiences.
Ching-Chang Kuo, Ching-Chang Kuo, Thao Ha, Thao Ha, Thao Ha, Ashley M. Ebbert, Ashley M. Ebbert, Don M. Tucker, Don M. Tucker, Don M. Tucker, Thomas J. Dishion, Thomas J. Dishion   +11 more
doaj   +1 more source

Localization of Eigenfunctions in the Stadium Billiard

, 2000
We present a systematic survey of scarring and symmetry effects in the stadium billiard. The localization of individual eigenfunctions in Husimi phase space is studied first, and it is demonstrated that on average there is more localization than can be ...
A. Bäcker, A. Bäcker, B. Eckhardt, B. Li, B. Li, E. B. Bogomolny, E. J. Heller, E. J. Heller, E. J. Heller, E. J. Heller, E. J. Heller, E. Vergini, F. P. Simonotti, G. Casati, G. Tanner, J. S. Espinoza Ortiz, L. Kaplan, L. Kaplan, L. Kaplan, L. Kaplan, L. Kaplan, M. R. Haggerty, M. Sieber, M. V. Berry, P. A. Boasman, P. W. O’Connor, P. W. O’Connor, S. D. Frischat, W. E. Bies   +28 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Localization of the Epileptogenic Zone Using High Frequency Oscillations

Frontiers in Neurology, 2019
For patients with drug-resistant focal epilepsy, surgery is the therapy of choice in order to achieve seizure freedom. Epilepsy surgery foremost requires the identification of the epileptogenic zone (EZ), defined as the brain area indispensable for ...
Aljoscha Thomschewski, Aljoscha Thomschewski, Ana-Sofía Hincapié, Birgit Frauscher   +3 more
doaj   +1 more source