Results 101 to 110 of about 14,058,743 (255)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Distribution of air parameters in premises with heat release sources
Инженерно-строительный журнал, 2012 The paper is devoted to control of air flows in premises with heat release sources. The modern numerical methods of heat and air exchange processes studies grounded on the equations of Navier – Stokes were utilized.
G.M. Pozin, V.M. Ulyasheva
doaj
Summary of Source Inclusion/Exclusion Process.
, 2015 Summary of Source Inclusion/Exclusion Process.
Leah Frerichs (778391) +6 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Institutional Repositories, Open Source Options, and Libraries [PDF]
, 2008 This paper examines the purposes of institutional digital repositories and the development options that are available via open source software. Preservation of an institution's digital output is valuable to the submitting authors and the institution ...
Amaral, Megan E.
core +1 more source
The process engraver's monthly.
Numbering continuous.Mode of access: Internet.Feb.-Aug. 1895, 1899- , Nov. 1903, The Process photogram; Apr. 1896-Feb. 1898, The Process photogram and illustrator (continued as caption title to Nov.
Federation of Master Process Engravers.
core
CIO herds and user gangs in the adoption of open source software [PDF]
Open Source Software (OSS) has received wide attention from the research community, analyzing both the innovation process of software development by distributed and unrelated teams, and the market dynamics at play between "free" and proprietary software.
Miralles, Francesc +2 more
core