Results 111 to 120 of about 14,058,743 (255)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
WOMEN IN OPEN SOURCE SOFTWARE INNOVATION PROCESS: WHERE ARE THEY?
Journal of ICT, 2012 The Open Source Software (OSS) Innovation process is no more a foreign face in the software development community as it is increasingly being used as a platform for modern software innovation both in the commercial and software research community ...
Musyrifah Mahmod, Zulkhairi Md Dahalin
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Preliminary result for the rupture process of Nov.13, 2017, Mw7.3 earthquake at Iran-Iraq border
Earth and Planetary Physics, 2018 WeiMin Wang +3 more
doaj +1 more source
Open Source Software Maintenance Process Framework
, 2005 To identify the Open Source maintenance process two well known Open Source projects Apache HTTP server and Mozilla web browser were studied. The Open Source software maintenance process is formal even anyone can submit modifications or defect reports to ...
Timo Koponen, Virpi Hotti
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Virtual and Physical PrototypingLaser powder bed fusion (LPBF) of Polyamide 12 (PA12) using a near-infra-red (NIR) beam is largely unexplored; therefore, the beam-matter interaction, evolution mechanisms of the melt pool and defects remain unclear. Here, we employed a combination of in
Chu Lun Alex Leung +7 more
doaj +1 more source
Connecting databases with process mining: a meta model and toolset
, 2016 Process Mining techniques require event logs which, in many cases, are obtained from databases. Obtaining these event logs is not a trivial task and requires substantial domain knowledge.
Van Der Aalst, W.M.P. +5 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source