Results 121 to 130 of about 10,574,194 (321)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A Generalized Bandsplit Neural Network for Cinematic Audio Source Separation

IEEE Open Journal of Signal Processing
Cinematic audio source separation is a relatively new subtask of audio source separation, with the aim of extracting the dialogue, music, and effects stems from their mixture.
Karn N. Watcharasupat, Chih-Wei Wu, Yiwei Ding, Iroro Orife, Aaron J. Hipple, Phillip A. Williams, Scott Kramer, Alexander Lerch, William Wolcott   +8 more
doaj   +1 more source

Combining Spatial Filtering and Sparse Filtering for Coaxial-Moving Sound Source Separation, Enhancement and Fault Diagnosis

IEEE Access, 2019
The wayside acoustic detector system is a potential technique in ensuring the safety of traveling vehicles. However, multisource aliasing and Doppler distortion in acquired acoustic signals decrease the accuracy of machine diagnosis.
Wei Xiong, Qingbo He, Kesai Ouyang, Zhike Peng   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evaluation of the Status of Citizen Participation in Municipal Waste Source Separation Plan and Offering Corrective Strategies

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2013
Background and Objectives: To implement source separation plan, awareness of viewpoints and participation of waste producers are necessary. The aim of this research is to assess the status of the source separation of municipal wastes and to offer its ...
Mohammad Fahiminia, Mahdi Farzadkia, Shahram Nazari, Shahram Arsang Jang, Alizadeh Soudabeh Matboo, Abdollah Ibrahimi, Majid Bidekhti   +6 more
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Deep Remix: Remixing Musical Mixtures Using a Convolutional Deep Neural Network

, 2015
Audio source separation is a difficult machine learning problem and performance is measured by comparing extracted signals with the component source signals.
Plumbley, Mark D., Roma, Gerard, Simpson, Andrew J. R   +2 more
core  

Factors influencing source separation intention and willingness to pay for improving waste management in Bangkok, Thailand

, 2018
Source separation for recycling has been recognized as a way to achieve sustainable municipal solid waste (MSW) management. However, most developing countries including Thailand have been facing with lack of recycling facilities and low level of source ...
Sujitra Vassanadumrongdee, Suthirat Kittipongvises   +1 more
semanticscholar   +1 more source