Results 71 to 80 of about 7,194,405 (289)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Loneliness: A Concept Analysis [PDF]

open access: yes, 2008
TOPIC. Loneliness is a universal human experience recognized since the dawn of time, yet it is unique for every individual. Loneliness can lead to both depression and low self‐esteem. PURPOSE. This article explicates the concept of loneliness through the
Bekhet, Abir K.   +1 more
core   +1 more source

Interference Channels With Arbitrarily Correlated Sources

open access: yes, 2009
Communicating arbitrarily correlated sources over interference channels is considered in this paper. A sufficient condition is found for the lossless transmission of a pair of correlated sources over a discrete memoryless interference channel.
Chen, Biao, Liu, Wei
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Beating Rayleigh's Curse by Imaging Using Phase Information

open access: yes, 2016
Any imaging device such as a microscope or telescope has a resolution limit, a minimum separation it can resolve between two objects or sources; this limit is typically defined by "Rayleigh's criterion", although in recent years there have been a number ...
Ferretti, Hugo   +2 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Educational Status, Aware Ness and Sources of Information of Osteoporosis Patients

open access: yesTürk Osteoporoz Dergisi, 2002
Osteoporosis is one of the major public health problems. Higher prevalence of most chronic diseases has been encountered in less educated subjects. Aim of this study was to assess educational status, knowledge and sources of information among subjects ...
Yeşim Gökçe Kutsal   +13 more
doaj  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Active Ontology: An Information Integration Approach for Dynamic Information Sources [PDF]

open access: yes, 2007
In this paper we describe an ontology-based information integration approach that is suitable for highly dynamic distributed information sources, such as those available in Grid systems.
Corcho, Oscar   +3 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

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