Results 151 to 160 of about 166,223,834 (257)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

De kiezende burger en het nieuwe zorgstelsel. Case Study naar de invloed van leeftijd, geslacht en opleiding op het gebruik van oude en nieuwe media als informatiebron. [PDF]

, 2007
LSG Management of Meaning (MOM), Mante-Meijer, E.A., Management of Meaning, Loos, E.F.   +3 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

De Tweede loopgolf. Over groei en omvang van de loopsportmarkt en hoe de KNAU haar marktaandeel verder kan vergroten [PDF]

, 2006
LSG Management of Meaning (MOM), van Bottenburg, M., Management of Meaning   +2 more
core  

Sources of meaning and meaning-making practices in a Canadian French-immersion mathematics classroom

, 2018
International audienceResearch on the learning and teaching of mathematics in the context of language diversity has highlighted how students make use of many different features of language in mathematical meaning-making, such as gestures, code-switching,
Barwell, Richard
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Globalization, Inequality and Olympic Sports Successes [PDF]

, 2004
LSG Management of Meaning (MOM), Wilterdinck, N., van Bottenburg, M., Management of Meaning, Universiteit Utrecht   +4 more
core  

Journal of Power Sources

The Journal of Power Sources (IF 6.333) is the journal for researchers and technologists interested in all aspects of the science, technology and applications of sources of electrochemical power.
ARBIZZANI, CATIA
core   +1 more source