Results 41 to 50 of about 3,221,844 (374)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Factors shaping innovation cooperation between companies and research and development institutions exemplified by the case of south-western Poland [PDF]

, 2013
The aim of this paper is the presentation of the probit models analysis factors shaping innovation cooperation between companies and research. The practical issue is exemplified by the case of south –western Poland.
Tomaszewski, Marek
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Patterns of Official Development Assistance in Tajikistan: effects on growth and poverty reduction [PDF]

Revista Brasileira de Política Internacional, 2020
The aim of this paper is to assess the effect of official development assistance on economic growth and poverty reduction in Tajikistan, as well as to examine the recent role of South-South Cooperation.
Mubinzhon Abduvaliev, Ricardo Bustillo
doaj   +1 more source

South-south cooperation and economic order [PDF]

, 2008
Regional associations between developing countries have so far often proved to be less than successful. This, Professor Altmann points out, is hardly surprising in view of the lack of homogeneity of socio-political and economic systems among member ...
Altmann, Jörn
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

South-South Paradiplomacy: A Channelling Mechanism of Denpasar-Mossel Bay Sister-City Cooperation

Journal of Paradiplomacy and City Networks
The practice of paradiplomacy in the Global South countries is currently on the rise. While prior studies have predominantly focused on Global North paradiplomacy, this paper demonstrates how legal regimes structurally channel paradiplomacy yet remain ...
Isti Nur Rahmahwati, Jevons Kollie Kawala   +1 more
doaj   +1 more source

COMPARE Forum: The idea of North-South and South-South collaboration [PDF]

, 2013
The idea of having a Compare Forum focusing on the above title was first discussed with one of the Editors of Compare during a PhD defence in Oslo in 2011.
Abdenur A., Abdi A., Alawia I. Farag, Anders Breidlid, Arnfinn Helleve, Breidlid A., Brock-Utne B., Chisholm L., De Wit Hans, De Wit Hans, Engeström Y., Fitzsimons P., Gutierrez K. D., Gutiérrez K., Halla B. Holmarsdottir, Jules T. D., King K., King K., Knight Jane, Knight Jane, Louis Royce Botha, Mangi J. Ezekiel, Meyer L., Modi R., Poole D. L., Richter S. M., Samoff J., Samoff J., Sheri Bastien, Sá e Silva M. M., Vuyokazi Nomlomo, Wanjiru Mukoma, Zubeida Desai   +32 more
core   +1 more source

The BRICS Effect: Impacts of South–South Cooperation in the Social Field of International Development Cooperation

The IDS Bulletin, 2018
The growing number of development stakeholders and initiatives in developing countries has added complexity to international development cooperation (IDC). Recipient countries have witnessed the increasing presence of emerging countries such as the BRICS
Geovana Zoccal Gomes, Paulo Esteves
semanticscholar   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source