Results 71 to 80 of about 1,201,228 (300)
Advanced Science, EarlyView.The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen +15 more
wiley +1 more source
Meridiano 47, 2011 A presente análise tem como foco analisar os possíveis rumos da política exterior brasileira no que tange às relações com a África.
Wolfgang Döpcke
doaj
Caderno CRHO principal objetivo deste artigo é, com base nas limitações críticas apontadas à experiência histórica da Cooperação Norte-Sul (CNS), analisar alguns dos dilemas com que se confrontam as atuais estratégias de Cooperação Sul-Sul (CSS), concebidas e ...
Carlos R. S. Milani
doaj +1 more source
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Carta Internacional, 2016 The international system in general, and the international cooperation for development specifically, have been through important changes in the last decades.
Paulo Esteves +2 more
doaj +1 more source
South-south cooperation and economic order [PDF]
, 2008 Regional associations between developing countries have so far often proved to be less than successful. This, Professor Altmann points out, is hardly surprising in view of the lack of homogeneity of socio-political and economic systems among member ...
Altmann, Jörn
core +1 more source
Advanced Science, EarlyView.HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li +13 more
wiley +1 more source
Brazilian and Chinese Cooperation in African Agriculture. A Practice-based Study
Íconos, 2013 In this article we analyze Brazilian and Chinese practices in terms of cooperation in Africa, focusing on the agricultural sector. While a great deal of work has analyzed the engagement of these emerging players from an international relations ...
Frédéric Goulet +2 more
doaj +1 more source
Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment
Advanced Science, EarlyView.Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun +5 more
wiley +1 more source
How South Korean Means Support North Korean Ends: Crossed Purposes in Inter-Korean Economic Cooperation [PDF]
North and South Korea share the same political and strategic aim of integration and eventual unification of Korea, although they remain divided in their understanding of what should be the specific nature of the unified Korea.
Smith, Hazel Anne
core