Results 31 to 40 of about 1,990,292 (309)
A Cross-regional Comparison of Selected European Newspaper journalists and their Evolving Attitudes and Beliefs about the Internet - including a single-country focus on the UK. [PDF]
, 2011 This study approaches how journalists in the United Kingdom might compare with individuals working in print journalism in 10 other European countries, to assess role perceptions and beliefs in relation to the internet.
Balcytiene, Aukse +7 more
core +1 more source
Constructing South East Europe [PDF]
, 2011 In the post-Cold War era, the Balkans came to exemplify the power of resurgent nationalisms freed from the straitjacket of bipolar stability. The break-up of the Yugoslav federation suggested that exclusivist ethno-national identities trumped the logic of political and economic integration.
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Journal for ImmunoTherapy of Cancer, 2022 Background Immune checkpoint inhibitors (ICI) have radically changed cancer therapy, but most patients with cancer are unresponsive or relapse after treatment. MK-5890 is a CD27 agonist antibody intended to complement ICI therapy. CD27 is a member of the
David Rosen +35 more
doaj +1 more source
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
Regional Educational Performance Patterns in Europe
Center for Educational Policy Studies Journal, 2011 The paper aims to contribute to the assessment of the contextual relevance of various educational policies through an analysis of three aspects of the performance profiles of European countries: participation, the quality of learning outcomes and the ...
Péter Radó
doaj +1 more source
Costs and benefits of the cap reform [PDF]
, 1992 This working paper presents a cost-benefit analysis of the reform of the Common Aqricultural policy (CAP) considering both its effects on farmers in the European Community (EC) and on farmers in third countries.
San Juan, Carlos
core +1 more source