Results 51 to 60 of about 6,499,713 (296)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Climate variability and human impact in South America during the last 2000 years: synthesis and perspectives from pollen records [PDF]

, 2016
An improved understanding of present-day climate variability and change relies on high-quality data sets from the past 2 millennia. Global efforts to model regional climate modes are in the process of being validated against, and integrated with, records
Rull, V., Gosling, William D., Hoyos, I., Flantua, Suzette, Carson, John F., Gosling, W., D, Ledru, Marie-Pierre, M. Vuille, González-Arango, C., Ledru, M., P, Ledru, M.P., Hooghiemstra, Henry, H. Hooghiemstra, H. Behling, Gosling, W.D.; id_orcid, Vuille, Mathias, Carson, J. F., Flantua, S.G.A., Maldonado, A., Carson, J.,, Behling, H., Tonello, M. S., Rull, Valentí, M. P. Ledru, Carson, J., F, J. F. Carson, Tonello, M., S, Ledru, M. P., Mayle, F., E. Montoya, A. Maldonado, Gosling, W. D., Carson, J.F., Tonello, M.S., Carson, J. F., Whitney, B., S, Hoyos, Isabel, Ledru, M.,, C. González-Arango, Gosling, William, Whitney, B. S., Montoya, Encarni, Flantua, S., G A, Mayle, Francis, González-Arango, Catalina, Whitney, Bronwen, Hooghiemstra, H., Tonello, M.,, I. Hoyos, S. G. A. Flantua, Montoya, E., M. S. Tonello, B. S. Whitney, Flantua, S. G. A., V. Rull, Maldonado, Antonio, Behling, Hermann, Vuille, M., Whitney, B.S., Flantua, Suzette G. A., F. Mayle, Whitney, B.,, Gosling, W.,, Gosling, W.D., W. D. Gosling, Flantua, S.,   +65 more
core   +5 more sources

Projected response of global runoff to El Niño-Southern oscillation

Environmental Research Letters, 2021
The El Niño-Southern Oscillation (ENSO) is a major mode of interannual climate variability and is expected to affect runoff variations at a global scale.
Thanh Le, Kyung-Ja Ha, Deg-Hyo Bae
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mosses of Peatlands in Isla Grande de Chiloé - Chile: keys for identification

Gayana: Botanica, 2018
The bryophytes play a key role in the peat bogs. However, knowledge of this group is scarce in southern South America. We present an identification key for peat moss from the Isla Grande de Chiloé (Chile).
Carolina A. León, Juan Larraín, Gisela Oliván-Martínez   +2 more
doaj  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Oribatid mites (Acariformes: Sarcoptiformes) in Sub-Antarctic Islands and Antarctica: a track analysis

Український антарктичний журнал
Southern non-marine mites are widely distributed in the continents that developed out of the macrocontinent Gondwana, with similar groups found in Australia, New Zealand, Sub-Antarctic Islands, and southern South America.
Patricio R. De los Ríos-Escalante, Pedro Jara-Seguel, Emmanuel O. Ahaotu   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source