Results 141 to 150 of about 2,104,489 (266)

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

open access: yesAdvanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding   +12 more
wiley   +1 more source

Trends, patterns and outcomes in hospitalisations for Alzheimer's disease: a 14-year retrospective analysis in Southwest China (2011-2024). [PDF]

open access: yesBMJ Open
Fu J   +12 more
europepmc   +1 more source

September 2015: Southwest Climate Outlook

open access: yes, 2015
This item from the Southwest Climate Outlook collection is made available by Climate Assessment for the Southwest (CLIMAS) at the University of Arizona with support from the University of Arizona Libraries.
Climate Assessment for the Southwest (CLIMAS)
core  

Soil pH Amelioration Synergizes Carbon Accrual with Yield Gains Under Organic Substitution

open access: yesAdvanced Science, EarlyView.
Soil pH shifts towards neutrality in both acidic and alkaline soils under organic substitution. A global synthesis links pH amelioration to soil organic carbon accrual through enhanced microbial biomass after accounting for added organic carbon and its interaction with pH. This pH amelioration‐shared soil organic carbon accrual accounts for 5.1–8.6% of
Xunzhuo Dong   +7 more
wiley   +1 more source

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

open access: yesAdvanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li   +8 more
wiley   +1 more source

Immunomagnetic‐MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor‐Derived Exosomes

open access: yesAdvanced Science, EarlyView.
An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin   +8 more
wiley   +1 more source

Factors Influencing the Implementation of Unaccompanied Care for Older Inpatients in Chinese Tertiary Hospitals: A Qualitative Study [Response to Letter]

open access: yesPatient Preference and Adherence
Yaping He,1,* Ruilian Li,1,* Taofang Jiao,1 Chunyu Liu,1 Ying Chen,1 Li Li2 1School of Nursing, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of Nursing, the Affiliated Hospital ...
He Y, Li R, Jiao T, Liu C, Chen Y, Li L
doaj  

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