Results 51 to 60 of about 5,650 (310)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Would an earlier inception of OMT by the ECB have prevented the 2012 Greek default?
International Review of Economics & FinanceTo avert further debt crises following the Greek default of 2012, the European Central Bank (ECB) adopted outright purchases of sovereign bonds as part of its monetary policy regime. This paper examines whether an earlier inception of such purchases (OMT)
Nicolas Mäder
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Empirical Evidence on Selective Sovereign Defaults
EkonomistaThis paper introduces a new empirical measure of fiscal fragility, specifically defined by fluctuations in the government’s tax base, to analyze selective sovereign defaults on domestic and foreign debts.
Wojciech Paczos
doaj +1 more source
Credit crunch: Chinese infrastructure lending and Lao sovereign debt
Asia & the Pacific Policy Studies, 2021 Lao PDR's push for large infrastructure‐led economic growth has been delivered through a significant amount of financial leverage and a build‐up of sovereign debt obligations. The government now finds itself in danger of a sovereign default. This article
Keith Barney, Kanya Souksakoun
doaj +1 more source
Review of International Political Economy, 2021 Scholars continue to debate why states repay their debts to foreign creditors. The existing literature stresses the short-term economic and political costs that deter default, focusing on reputational damage, creditor reprisals, spillover costs, and loss of office.
openaire +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
SOVEREIGN RISK ANALYSIS OF DEVELOPING COUNTRIES: FINDINGS FROM CREDIT DEFAULT SWAP PREMIUM BEHAVIOUR
Buletin Ekonomi Moneter dan Perbankan, 2011 This study conducts econometric analysis CDS Premium relations towards variables usually used as a sovereign rating explanatory. Estimation with data panel econometric found that global risk appetite is the most important influencing variable followed by
Moch Doddy Ariefianto +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
DRIVERS OF ILLIQUIDITY IN THE ASEAN SOVEREIGN BOND MARKET
Buletin Ekonomi Moneter dan Perbankan, 2020 We study illiquidity in ASEAN-5 sovereign bond markets from 2008 to 2019 by using an illiquidity measure, which is based on a proxy of the amount of arbitrage capital available in sovereign bond markets.
Harald Kinateder +2 more
doaj +1 more source