Results 201 to 210 of about 5,726,311 (302)
Advanced Science, EarlyView.Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu +8 more
wiley +1 more source
Sovereign Debt, Volatility and Insurance [PDF]
External debt increases the vulnerability of indebted emerging market economies to macroeconomic volatility and financial crises. Capital account reversals often lead to sovereign debt repayment crises that are only resolved after prolonged and difficult
Kenneth Kletzer
core
Bank Resolution Trade-Offs Under Coupled Liquidity and Credit Risks: An Agent-Based Network Analysis of Systemic Stability. [PDF]
Entropy (Basel)Gao Q, Pan H, Liu Y, Chen N.
europepmc +1 more source
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
Artificial intelligence for climate-health early warning systems in the Horn of Africa: opportunities, challenges, and a roadmap for action. [PDF]
Global HealthAlasow AA, Abdi YH, Hersi AA, Boakye M.
europepmc +1 more source
Informal creditors and sovereign debt restructuring. [PDF]
Indian Econ Rev, 2023 Ghosal S, Thomas D.
europepmc +1 more source
Engineered Transformer Base Editor with Enhanced Editing Efficiency
Advanced Science, EarlyView.A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen +5 more
wiley +1 more source
The Health of Nations Fund: Financing global drug development. [PDF]
PLOS Glob Public HealthCho J +4 more
europepmc +1 more source
Advanced Science, EarlyView.The WTP is a key component of static drainage PEMFCs, enabling cathode water removal and gas sealing through capillary forces. This work investigates the mechanisms governing WTP drainage and sealing performance and develops predictive approaches for WTP design optimization.
Mengdi Guo +3 more
wiley +1 more source
The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy
Advanced Science, EarlyView.Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi +11 more
wiley +1 more source