Results 51 to 60 of about 21,955 (297)

Internal debt crises and sovereign defaults [PDF]

open access: yesJournal of Monetary Economics, 2014
Internal and sovereign debt crises occur together and happen more frequently in economies with weak bankruptcy institutions. This paper provides a novel explanation. Internal crises arise because of the inability to liquidate private debtors when many default. In an optimal contract, a successful entrepreneur repays yet an unsuccessful one defaults and
Cristina Arellano   +1 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Debt Dilution and Sovereign Default Risk [PDF]

open access: yesIMF Working Papers, 2011
In this study, we measure the effects of debt dilution on sovereign default risk and consider debt covenants that could mitigate these effects. First, we calibrate a baseline model of defaultable debt (in which debt can be diluted) with endogenous debt duration, using data from Spain.
Juan Carlos Hatchondo   +2 more
openaire   +5 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

The heterogeneity of default costs: Evidence from recent sovereign debt crises [PDF]

open access: yes, 2011
This paper examines the costs of recent sovereign defaults using synthetic control methods, a novel econometric technique based on comparative case studies.
Jorra, Markus
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

The Sustainable Debts of Philip II: A Reconstruction of Castile's Fiscal Position, 1566-1596 [PDF]

open access: yes
The defaults of Philip II have attained mythical status as the origin of sovereign debt crises. We reassess the fiscal position of Habsburg Castile, deriving comprehensive estimates of revenue, debt, and expenditure from new archival data.
Drelichman, Mauricio, Voth, Hans-Joachim
core   +3 more sources

The Effect of IMF Lending on the Probability of Sovereign Debt Crises [PDF]

open access: yes
This paper explores empirically how the adoption of IMF programs affects sovereign risk over the medium term. We nd that IMF programs signifcantly increase the probability of subsequent sovereign defaults by approximately 1.5 to 2 percentage points ...
Markus Jorra
core  

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Sovereign Default Analysis through Extreme Events Identification

open access: yesManagement Dynamics in the Knowledge Economy, 2015
This paper investigates contagion in international credit markets through the use of a novel jump detection technique proposed by Chan and Maheuin (2002).
Vasile George MARICA   +1 more
doaj  

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