Results 161 to 170 of about 945 (260)

Private investments in climate change adaptation are increasing in Europe, although sectoral differences remain. [PDF]

Commun Earth Environ
Cortés Arbués I, Chatzivasileiadis T, Storm S, Ivanova O, Filatova T.   +4 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Redefining Debt-to-Health, a triple-win health financing instrument in global health. [PDF]

Global Health
Hu Y, Wang Z, Zhou S, Yang J, Chen Y, Wang Y, Xu M.   +6 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

BioStruct-Africa's scalable framework for AlphaFold-enabled research training and sustainable workforce development in Africa. [PDF]

Commun Biol
Amofa JO, George J, Okumu NA, Ohene M, Terefe EM, Tsomene SL, Tougue OC, Bejide IO, Nabukeera KC, Nelson AY, Tagne CSD, Osabutey PY, Ndiaye A, Nkwe DO, Ohaekenyem EC, Jolaiya TF, Banda H, Ikponmwosa-Eweka O, N David W, Ekpenyong BB, Segda A, Diabate O, Jarso AH, Arafat K, Elrashedy A, Yadeta MM, Richard ZB, Omara IE, Ndaba T, Ejiofor II, Magwell PFR, Sedeek M, Lazaro LO, Nyoni RM, Oketch RA, Odur W, Hassan YM, Ambala P, Chandipwisa C, Bassey OP, Ondari LN, Jonah UG, Amoussou CA, Kyomukama RC, Yamssi C, James SC, Kone AK, Ndiaye O, Ssenfuka H, Nyang'au AK, Amos Y, Kawalya H, Mware B, Adundo WJ, Ngannang-Fezeu VB, Tandja AG, Abdellatif AH, Omowumi OF, Luutu NM, Kouman AKB, Soliman DS, Essilfie NK, Wabwile JJ, Sankhe S, Fofana FG, Heiba W, Nasser Y, Djikeng A, Akurut E, Walakira A, Moumbock AFA, Griese JJ, Tiengwe C, Ndi M, Martin IS, Fodje M, Rüffin NV, Cramer KC, Davis J, Nji E.   +79 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Empowering Privacy Through Peer-Supervised Self-Sovereign Identity: Integrating Zero-Knowledge Proofs, Blockchain Oversight, and Peer Review Mechanism. [PDF]

Sensors (Basel)
Liu J, Liang Z, Lyu Q.
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Does BRRD mitigate the bank-to-sovereign risk channel? [PDF]

PLoS One
Lamers M, Present T, Soenen N, Vennet RV.   +3 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source