Results 201 to 210 of about 783,154 (338)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Investors reward countries for participating in climate agreements. [PDF]

Nat Commun
Saxena K, Singh M.
europepmc   +1 more source

The effect of Eurosystem asset purchase programmes on euro area sovereign bond yields during the COVID-19 pandemic. [PDF]

Empir Econ, 2022
Hondroyiannis G, Papaoikonomou D.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

American Indian community engagement and the structural and social determinants of health: results from the THRIVE assessment. [PDF]

Front Public Health
Webb K, Posey S, Hirchak K, Beamon E, Milligan K, Wagon S, Fatupaito B, Kelley A.   +7 more
europepmc   +1 more source

COVID-19 and credit risk: A long memory perspective. [PDF]

Insur Math Econ, 2022
Yin J, Han B, Wong HY.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

BioStruct-Africa's scalable framework for AlphaFold-enabled research training and sustainable workforce development in Africa. [PDF]

Commun Biol
Amofa JO, George J, Okumu NA, Ohene M, Terefe EM, Tsomene SL, Tougue OC, Bejide IO, Nabukeera KC, Nelson AY, Tagne CSD, Osabutey PY, Ndiaye A, Nkwe DO, Ohaekenyem EC, Jolaiya TF, Banda H, Ikponmwosa-Eweka O, N David W, Ekpenyong BB, Segda A, Diabate O, Jarso AH, Arafat K, Elrashedy A, Yadeta MM, Richard ZB, Omara IE, Ndaba T, Ejiofor II, Magwell PFR, Sedeek M, Lazaro LO, Nyoni RM, Oketch RA, Odur W, Hassan YM, Ambala P, Chandipwisa C, Bassey OP, Ondari LN, Jonah UG, Amoussou CA, Kyomukama RC, Yamssi C, James SC, Kone AK, Ndiaye O, Ssenfuka H, Nyang'au AK, Amos Y, Kawalya H, Mware B, Adundo WJ, Ngannang-Fezeu VB, Tandja AG, Abdellatif AH, Omowumi OF, Luutu NM, Kouman AKB, Soliman DS, Essilfie NK, Wabwile JJ, Sankhe S, Fofana FG, Heiba W, Nasser Y, Djikeng A, Akurut E, Walakira A, Moumbock AFA, Griese JJ, Tiengwe C, Ndi M, Martin IS, Fodje M, Rüffin NV, Cramer KC, Davis J, Nji E.   +79 more
europepmc   +1 more source

The determinants of sovereign risk premiums in the UK and the European government bond market: the impact of Brexit. [PDF]

Int Econ Econ Policy, 2022
Kadiric S.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source