Results 131 to 140 of about 5,547,723 (304)
ResourcesWater scarcity is increasingly recognized as a macroeconomic challenge, yet its implications for sovereign financing conditions remain insufficiently understood.
Ezer Ayadi
doaj +1 more source
Funding Empire: Risk, Diversification, and the Underwriting of Early Modern Sovereign Loans. [PDF]
Lending to early modern monarchs could be very profitable, yet highly risky. International financiers unlocked the excess returns in sovereign debt markets by parceling out the risk and transferring it to downstream investors in exchange for financial ...
Voth, Hans-Joachim, Drelichman, Mauricio
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
THE SOVEREIGN DEBT CHALLANGE: AN OVERVIEW [PDF]
Annals of the University of Oradea: Economic Science, 2011 Recent years have seen profound changes in country risk and its components, in the context of crises multiplication and diversification; the sovereign risk, a main country risk component, has undergone important changes, mainly given by mutations in its ...
Pop Stanca +2 more
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Sovereign credit ratings [PDF]
This paper describes sovereign credit ratings in emerging markets both for a specific year and over time, using quantitative explanatory variables. It turns out that rating adjustments have been worse than what economic fundamentals justify for some ...
Eliasson, Ann-Charlotte
core +2 more sources
What can EMU countries' sovereign bond spreads tell us about market perceptions of default probabilities during the recent financial crisis? [PDF]
This paper presents a new approach for analysing the recent development of EMU sovereign bond spreads. Based on a GARCH-in-mean model originally used in the exchange rate target zone literature, spreads are decomposed into a risk premium, an expected ...
Fischer, Christoph, Dötz, Niko
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Impact of Geopolitical Risk on the Connectedness Dynamics Among Sovereign Bonds
MathematicsThis study examines the impact of geopolitical risk (GPR) on the connectedness dynamics among the sovereign bonds of the emerging seven (E7) and the Group of Seven (G7) countries.
Mustafa Almabrouk Abdalla Alfughi +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source