Results 81 to 90 of about 15,046 (302)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Sovereign Risk: A Reappraisal [PDF]

open access: yesSSRN Electronic Journal, 2013
The Greek drama of the late 2000s has returned sovereign risk awareness to centre stage. The default affected a country with a relatively developed economy. It resulted in huge losses for the value of domestic assets: public debt, but also private debt, equity, real estate and furthermore pension rights and human capital.
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

A Pyrrhic Victory? - Bank Bailouts and Sovereign Credit Risk [PDF]

open access: yes
We show that financial sector bailouts and sovereign credit risk are intimately linked. A bailout benefits the economy by ameliorating the under-investment problem of the financial sector.
Philipp Schnabl   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Sovereign risk in a structural approach: Evaluating sovereign ability-to-pay and probability of default [PDF]

open access: yes
We quantify the probability that a sovereign defaults on repayment obligations in foreign currency. Adopting the structural approach as first introduced by Merton, we consider the sovereigns ability-to-pay, characterised by the sum of discounted future ...
Maltritz, Dominik, Karmann, Alexander
core  

Sovereign and sub sovereign default risk under currency boards: Is there a link in a federal state? Argentina 1997-2001

open access: yesRevista de Economía Política de Buenos Aires, 2018
This paper aims to test whether the average sovereign bond spread was statistically different from the average provincial spread in Argentina during 1997-2001, that is if investors perceived that Argentina’s default risk being a federal country should ...
Martín Grandes, Gerardo della Paolera
doaj   +2 more sources

Sovereign ratings: Determinants and policy implications for India

open access: yesIIMB Management Review, 2018
This paper studies sovereign rating models of Moody's, Standard & Poor's (S&P) and Fitch to identify important determinants of sovereign ratings. Ordered logit and probit are employed to check for robustness of empirical results.
Sanjay Sehgal   +3 more
doaj   +1 more source

On the risk of sovereign exposures [PDF]

open access: yesČeský finanční a účetní časopis, 2019
Clanek v obecne rovině charakterizuje svrchovane riziko a riziko přilisne koncentrace svrchovaných expozic v bilancich bank a na zakladě analýzy vývoje tohoto jevu ve sledovanem obdobi v CR, resp. dalsich vybraných statech, posuzuje miru ucinnosti postoje centralni banky CR k tomuto potencialnimu zdroji financni nestability.
openaire   +1 more source

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