Results 221 to 230 of about 3,830,532 (256)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

High-Moisture Extrusion of Plant-Based Meat Analogues: Challenges and Opportunities. [PDF]

Foods
Karki S, More R, Attenborough E, Dhital S.   +3 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Extrusion-Structured Plant-Based Meat Analogs: Factors Governing Texture and Quality. [PDF]

Prev Nutr Food Sci
Gu BJ, Han A, Jeon H, Jeong J, Ryu GH.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Bio-Based Brewer's Spent Grain Particleboards: Effect of Rosin Coating and Wood Veneer Reinforcement on Structure and Properties. [PDF]

Polymers (Basel)
Rossi L, Rueda F, Ciannamea EM, Stefani PM.   +3 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Effects of novel specialty soy protein products on growth performance and fecal dry matter of nursery pigs. [PDF]

Transl Anim Sci
Smallfield JL, Tokach MD, Woodworth JC, DeRouchey JM, Gaffield KN, Goodband RD, Gebhardt JT, Warner AJ, Hastad CW, Zou L, May SB, Schweer WP, Pilcher CM.   +12 more
europepmc   +1 more source

Conventional and Emerging Protein Ingredients in Farinaceous Products: Amino Acid Quality, Digestibility, Biological Value, and Functional Performance. [PDF]

Compr Rev Food Sci Food Saf
Álvarez-Arteaga P, Lazo-Vélez MA, Mateo Cordero-Clavijo L, Paterson S.   +3 more
europepmc   +1 more source