Results 131 to 140 of about 734,345 (337)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A Fast IAA–Based SR–STAP Method for Airborne Radar

Remote Sensing
Space–time adaptive processing (STAP) is an effective technology in clutter suppression and moving target detection for airborne radar. When working in the heterogeneous environment, the number of training samples that satisfy independent and identically
Shuguang Zhang, Tong Wang, Cheng Liu, Bing Ren   +3 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A novel sparse recovery space‐time adaptive processing algorithm using the log‐sum penalty to approximate the ℓ0 − norm penalty

IET Radar, Sonar & Navigation
Applying the sparse recovery (SR) technique to airborne radar space‐time adaptive processing (STAP) can greatly reduce the number of required training samples, which is advantageous in detecting targets in non‐homogeneous and non‐stationary clutter ...
Kun Liu, Tong Wang
doaj   +1 more source

Airborne Radar Space–Time Adaptive Processing Algorithm Based on Dictionary and Clutter Power Spectrum Correction [PDF]

Zhiqi Gao, Wei Deng, Pingping Huang, Wei Xu, Weixian Tan   +4 more
openalex   +1 more source

Sparse recovery‐based space‐time adaptive processing with array error self‐calibration [PDF]

, 2014
Zeqiang Ma, Yimin Liu, Huadong Meng, Xiqin Wang   +3 more
openalex   +1 more source

Real-time demonstration hardware for enhanced DPCM video compression algorithm [PDF]

The lack of available wideband digital links as well as the complexity of implementation of bandwidth efficient digital video CODECs (encoder/decoder) has worked to keep the cost of digital television transmission too high to compete with analog methods.
Bizon, Thomas P., Marcopoli, Vincent R., Whyte, Wayne A., Jr.   +2 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source