Results 41 to 50 of about 20,281,849 (282)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Multichannel Sea Clutter Measurement and Space-Time Characteristics Analysis with L-Band Shore-Based Radar

Remote Sensing, 2022
In order to study the space-time characteristics of sea clutter, the sea clutter is always measured by the airborne multichannel radar; however, the sea clutter shows the heterogeneity between range gates, which means the space-time covariance matrix’s ...
Jintong Wan, Feng Luo, Yushi Zhang, Jinpeng Zhang, Xinyu Xu   +4 more
doaj   +1 more source

Exploiting persymmetry for low-rank Space Time Adaptive Processing [PDF]

Signal Processing, 2014
Publication in the conference proceedings of EUSIPCO, Bucharest, Romania ...
Ginolhac, Guillaume, Forster, Philippe, Pascal, Frédéric, Ovarlez, Jean-Philippe   +3 more
openaire   +6 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Adaptive Bayesian Space-Time Equalisation for Multiple Receive-Antenna Assisted Single-Input Multiple-Output Systems

, 2008
This contribution considers nonlinear space–time equalisation (STE) for multiple receive-antenna induced single-input multipleoutput (SIMO) systems. By exploiting the inherent symmetry of the underlying optimal Bayesian STE solution, a novel symmetric ...
Liu, Sheng, Chen, Sheng, Hanzo, Lajos
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Minimum bit-error rate design for space-time equalization-based multiuser detection

, 2006
A novel minimum bit-error rate (MBER) space–time equalization (STE)-based multiuser detector (MUD) is proposed for multiple-receive-antenna-assisted space-division multiple-access systems. It is shown that the MBER-STE-aided MUD significantly outperforms
Chen, Sheng, Livingstone, A., Hanzo, L.
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source