Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Layered Steered Space-Time Codes and their capacity [PDF]
A capacity analysis of a multifunctional multiple-input multiple-output system that combines the benefits of vertical Bell Labs space-time scheme, space-time block codes and beamforming is ...
El-Hajjar, M., Hanzo, L.
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Joint Estimation and Decoding of Space-Time Trellis Codes
We explore the possibility of using an emerging tool in statistical signal processing, sequential importance sampling (SIS), for joint estimation and decoding of space-time trellis codes (STTC).
Zhang Jianqiu, Djurić Petar M
doaj +1 more source
Algebraic Distributed Space-Time Codes with Low ML Decoding Complexity
"Extended Clifford algebras" are introduced as a means to obtain low ML decoding complexity space-time block codes. Using left regular matrix representations of two specific classes of extended Clifford algebras, two systematic algebraic constructions of
Rajan, B. Sundar, Rajan, G. Susinder
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Successive Interference Cancellation for DS-CDMA Systems with Transmit Diversity
We introduce a new successive interference cancellation (SIC) technique for direct sequence code division multiple access (DS-CDMA) systems with transmit diversity. The transmit diversity is achieved with a space-time block code (STBC).
Li Wei, Gulliver T. Aaron
doaj +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Comprehensive Performance Analysis of Fully Cooperative Communication in WBANs
While relay-based cooperative networks (widely known in the literature as cooperative communication), where relays only forward signals from the sources to the destination, have been extensively researched, fully cooperative systems have not been ...
L. C. Tran +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source

