Results 61 to 70 of about 18,141,497 (258)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

OFDMA/SC-FDMA Aided Space–Time Shift Keying for Dispersive Multiuser Scenarios [PDF]

IEEE Transactions on Vehicular Technology, 2013
Motivated by the recent concept of space-time shift keying (STSK), which was developed for achieving a flexible diversity versus multiplexing gain tradeoff, we propose a novel orthogonal frequency-division multiple access (OFDMA)/single-carrier frequency-division multiple-access (SC-FDMA)-aided multiuser STSK scheme for frequency-selective channels ...
Mohammad Ismat Kadir, Shinya Sugiura, Jiayi Zhang 0001, Sheng Chen 0001, Lajos Hanzo   +4 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Fully Breaking Entanglement of Multiple Harmonics for Space‐ and Frequency‐Division Multiplexing Wireless Applications via Space‐Time‐Coding Metasurface

Advanced Science
Harmonic generation and utilization are significant topics in nonlinear science. Although the progress in the microwave region has been expedited by the development of time‐modulated metasurfaces, one major issue of these devices is the strong ...
Zhangjie Luo, Zhiming Zhang, Junwei Tai, Lei Zhang, Chenglong Gao, Hui Feng Ma, Wei Xiang Jiang, Qiang Cheng, Tie Jun Cui   +8 more
doaj   +1 more source

PERFORMANCE ANALYSIS OF MIMO-SPACE TIME BLOCK CODING WITH DIFFERENT MODULATION TECHNIQUES [PDF]

ICTACT Journal on Communication Technology, 2012
MIMO Diversity is the technique which takes the advantage of multipath and mitigates the effect of fading and increases signal strength. Space Time Block code (STBC) is used in Multiple Input Multiple Output (MIMO) system to improve the performance by ...
Shubhangi Chaudhary, A.J. Patil
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

MC-CDMA aided multi-user space-time shift keying in wideband channels

, 2013
In this paper, we propose multi-carrier code division multiple access (MC-CDMA)-aided space-time shift keying (STSK) for mitigating the performance erosion of the classic STSK scheme in dispersive channels, while supporting multiple users.
Mohammad Ismat Kadir, Sheng Chen, Sugiura, Shinya, Shinya Sugiura, Chen, Sheng, Kadir, Mohammad Ismat, Hanzo, Lajos, Lajos Hanzo   +7 more
core   +1 more source