Results 141 to 150 of about 704,635 (314)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
This book is an academic investigation of commercial activities of firms in the space related industries and those utilizing services provided by space technology firms.
core +1 more source
Commercial outer space activities [PDF]
, 2009 The history of the Law of the space. Commercial space actions under the conditions of the corpus iuris spatialis. The Law of space, private enterprise and private property. Communications via satellite. Space transportation.
Vitale, Salvatore
core
Long-Term Sustainability of Space Activities: Achievements and Prospects
, 2019 This article aims to highlight the main areas of discussion regarding long-term sustainability of space activities within the United Nations and assess the most significant challenges COPUOS has towards the establishment of a new working group to make
Jamschon Mac Garry, Laura +1 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 1993 The problem of space debris becomes more and more important. On a symposium, 10 papers covering this very serious subject were presented. The present contents of the papers are assigned to the following ares: description of the situation of space debris ...
Deutsche Agentur fuer Raumfahrtangelegenheiten (DARA) GmbH, Bonn (Germany)
core
, 2019 Over the last 10-20 years there has been an ever-increasing international awareness of risks to modern society from adverse and potentially harmful - and in extreme cases even disastrous - space weather events.
Hapgood, Mike +22 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2012 In June of 1999 the space operations leadership of seven space agencies met at European Space Agency (ESA) Headquarters to discuss steps which could be taken to facilitate international space operations strategic planning, including interoperability ...
Calzolari, Gian-Paolo +6 more
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source