Results 41 to 50 of about 5,734,949 (292)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Space charge behavior in multi-layer oil-paper insulation under different DC voltages and temperatures [PDF]

, 2010
Oil-paper as a reliable insulation system is widely used in power transformers and cables. The dielectric properties of oil-paper insulation play an important role in the reliable operation of power equipment. However, the formation and dynamics of space
Liao, Rujin, Fu, Mingli, Chao Tang, Rui-jin Liao, G. Chen, M. Fu, Tang, Chao, Chen, George   +7 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Investigation on space charge and charge trap characteristics of gamma-irradiated epoxy micro–nano composites

High Voltage, 2019
Epoxy nano–micro composite specimen prepared with micro silica and ion trapping nanoparticle, by shear mixing process, was exposed to gamma radiation and its performance for space charge and charge trap characteristics were analysed.
Myneni Sukesh Babu, Ramanujam Sarathi, Nilesh Jayantilal Vasa, Takahiro Imai   +3 more
doaj   +1 more source

High-Precision Inertial Sensor Charge Management Based on Ultraviolet Discharge: A Comprehensive Review

Sensors, 2023
The charge accumulation caused by cosmic rays and solar energetic particles poses a significant challenge as a source of noise for inertial sensors used in space gravitational wave detection. To address this issue, the implementation of charge management
Tao Yu, Yuhua Wang, Yang Liu, Zhi Wang
doaj   +1 more source

Accumulated space-charge in stationary- and steady-state

Journal de Physique III, 1992
Nous présentons une nouvelle approche de la description de la charge d'espace accumulée dans l'état stationnaire et statique dans une homostructure multicouches (n+-n-n+). L'évolution statique des populations accumulées de fractions de porteurs libres est considérée dans le cadre de l'approximation quasi-équilibre comme une fonction de la polarisation ...
openaire   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Effects of Trapping Characteristics on Space Charge and Electric Field Distributions in HVDC Cable under Electrothermal Stress

Energies, 2021
Space charge behavior has a strong impact on the long-term operation reliability of high voltage–direct current (HVDC) cables. This study intended to reveal the effect of trap density and depth on the space charge and electric field evolution behavior in
Fuqiang Tian, Shuting Zhang, Chunyi Hou
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Study on space charge accumulation characteristics of silicone elastomer under DC voltage

High Voltage
The electric field distortion caused by the accumulation of space charge in the insulating dielectric is easy to lead to accelerated ageing and even breakdown. In this paper, the space charge characteristics and the interfacial electric field change with
Jinqiang Zhang, Xuebao Li, Peng Sun, Zhibin Zhao, Xiang Cui, Xiaoguang Wei, Xinling Tang, Rui Jin   +7 more
doaj   +1 more source