Results 111 to 120 of about 11,957,490 (337)

Space-Efficient Latent Contracts [PDF]

, 2019
In post-proceedings of TFP 2016. Second revision extends to dependency; third fixes typos in the abstract; fourth is long version of what will be the final TFP ...
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Abnormal ore pressure mechanism of working face under the influence of overlying concentrated coal pillar

Scientific Reports
Shenfu Dongsheng coal field is a cross-century energy base which is developed and constructed in China. In recent years, some mines have successively entered to the coal seam of the second layer.
Cao Zhengzheng, Sun Qiang, Li Zhenhua, Du Feng   +3 more
doaj   +1 more source

Improving the efficiency of the detection of gravitational wave signals from inspiraling compact binaries: Chebyshev interpolation

, 2005
Inspiraling compact binaries are promising sources of gravitational waves for ground and space-based laser interferometric detectors. The time-dependent signature of these sources in the detectors is a well-characterized function of a relatively small ...
C. E. Shannon, G. H. Sanders, J. C. Mason, L. S. Finn, M. Ando, M. Matsumoto, M. J. D. Powell, S. Mitra, S. V. Dhurandhar   +8 more
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Designing For Vertical Needs: Creating A Ladder Chair For Ergonomic And Space-Saving Solutions

International Journal of Arts Architecture & Design
As creative and academic studio spaces grow increasingly constrained, the demand for multi-functional furniture solutions becomes more critical. This study focused on the design, fabrication, and evaluation of a multifunctional ladder chair that ...
Obed Persie Appiah-Kubi , Evans Kwadwo Donkor   +1 more
doaj   +1 more source

Characteristics of deformation and defect of shield tunnel in coastal structured soil in China

Underground Space
Shield tunnel is a type of linear underground structure assembled by lining segments, characterized with long joint, weak stiffness, and strict deformation control requirement. The situation of the long-term deformation and defect of the shield tunnel in
Fanyan Meng, Bo Hu, Renpeng Chen, Hongzhan Cheng, Huaina Wu   +4 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Adaptive multiresolution computations applied to detonations

, 2015
A space-time adaptive method is presented for the reactive Euler equations describing chemically reacting gas flow where a two species model is used for the chemistry.
Roussel, Olivier, Schneider, Kai
core   +3 more sources